{"id":"W3011406800","doi":"10.1016/j.redox.2020.101514","title":"Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor","year":2020,"lang":"en","type":"article","venue":"Redox Biology","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"National Natural Science Foundation of China; Harbin Medical University","keywords":"Spermine; Downregulation and upregulation; Diabetic cardiomyopathy; Calcium-sensing receptor; Internal medicine; Endocrinology; Oxidative stress; Unfolded protein response; Endoplasmic reticulum; Reactive oxygen species; Chemistry; Calcium; Calcium metabolism; Cell biology; Cardiomyopathy; Biology; Medicine; Biochemistry; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001084452,0.0001847654,0.0003403568,0.00004060907,0.00006692867,0.000007192028,0.0001624592,0.0002209991,0.00002312661],"category_scores_gemma":[0.0001642896,0.0001676401,0.0001135969,0.0001769981,0.0002264482,0.000004300576,0.0001214513,0.00008177243,0.00003106837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008251357,"about_ca_system_score_gemma":0.00005101083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002828281,"about_ca_topic_score_gemma":0.000003329941,"domain_scores_codex":[0.9987758,0.0001475566,0.00031962,0.0004139401,0.00006918641,0.0002738982],"domain_scores_gemma":[0.9992558,0.00004084802,0.0001598114,0.0002916438,0.0001312263,0.0001206845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005807709,0.00003077477,0.001170927,0.0000149025,0.00004989912,0.000001205491,0.0001015039,0.00002776107,0.9940031,0.0000450422,0.0004256133,0.004071202],"study_design_scores_gemma":[0.0004750484,0.0002014496,0.002936625,0.000006153577,0.0000478691,0.00001017871,0.00004484671,0.0003689453,0.9772905,0.00003980751,0.01838641,0.0001921359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895295,0.001579434,0.007201451,0.000756381,0.0001359822,0.0002658944,0.0003060071,0.00002638455,0.0001989695],"genre_scores_gemma":[0.9958696,0.0001559637,0.0008890357,0.0002992386,0.0005529164,0.00002627308,0.002133906,0.00002377972,0.00004930212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01796079,"threshold_uncertainty_score":0.6836166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01272626086540861,"score_gpt":0.2496492214704942,"score_spread":0.2369229606050856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}