{"id":"W3011438444","doi":"10.3389/fendo.2020.00124","title":"Behavioral Abnormalities in Knockout and Humanized Tau Mice","year":2020,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Queen's University; University of Toronto","funders":"Institute for Translational Neuroscience; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Alzheimer's Society; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Canadian Institutes of Health Research; Alzheimer Society; Diabetes Canada; Weston Brain Institute","keywords":"Tau protein; Genetically modified mouse; Knockout mouse; Neuroscience; Transgene; Gene knockin; Anxiety; Phenotype; Biology; Psychology; Disease; Internal medicine; Medicine; Alzheimer's disease; Gene; Genetics; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002544206,0.000133489,0.0003567885,0.000190995,0.00003016806,0.00000875208,0.0000737965,0.00005982446,0.0001100193],"category_scores_gemma":[0.00003280584,0.0001272488,0.00003955446,0.0001383866,0.0001839577,0.0000775679,0.00007891393,0.0002500027,0.00002583363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000732699,"about_ca_system_score_gemma":0.00005445809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002815979,"about_ca_topic_score_gemma":0.00004992286,"domain_scores_codex":[0.998842,0.000077153,0.0001985042,0.0002775054,0.0001202284,0.0004845813],"domain_scores_gemma":[0.9996123,0.00001875925,0.00002670191,0.0001167925,0.00002019236,0.0002052355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000654931,0.0003314264,0.9815747,0.00005909137,0.000451415,0.003092901,0.001236004,6.348272e-7,0.00004612769,0.0001799858,0.004217292,0.008155548],"study_design_scores_gemma":[0.03406081,0.002872367,0.9371085,0.0001228657,0.0006025761,0.0004331393,0.009665336,0.001211,0.001752271,0.001110489,0.01039714,0.0006634976],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982201,0.01439441,0.00002225685,0.001642143,0.0001285204,0.0003646871,0.000018581,0.00004253911,0.00118584],"genre_scores_gemma":[0.99708,0.0009186303,0.001415921,0.0003362504,0.00004983804,0.00005574734,0.00003112603,0.00001584,0.00009663912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04446613,"threshold_uncertainty_score":0.5189056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0384528415026672,"score_gpt":0.3165100086709264,"score_spread":0.2780571671682592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}