{"id":"W3011438444","doi":"10.3389/fendo.2020.00124","title":"Behavioral Abnormalities in Knockout and Humanized Tau Mice","year":2020,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Queen's University; University of Toronto","funders":"Institute for Translational Neuroscience; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Alzheimer's Society; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Canadian Institutes of Health Research; Alzheimer Society; Diabetes Canada; Weston Brain Institute","keywords":"Tau protein; Genetically modified mouse; Knockout mouse; Neuroscience; Transgene; Gene knockin; Anxiety; Phenotype; Biology; Psychology; Disease; Internal medicine; Medicine; Alzheimer's disease; Gene; Genetics; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005080969,0.002394593,0.0007969934,0.002928016,0.0007377585,0.0009883393,0.0008899362,0.001999503,0.007018189],"category_scores_gemma":[0.0004113372,0.0007662588,0.001107593,0.0007320658,0.001311873,0.0007762656,0.0007023825,0.002817207,0.00157399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009116764,"about_ca_system_score_gemma":0.0005929704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001639835,"about_ca_topic_score_gemma":0.002819306,"domain_scores_codex":[0.9990086,0.00007793192,0.0001371638,0.0004204803,0.0001786169,0.0001772394],"domain_scores_gemma":[0.9990877,0.00009444927,0.0004086422,0.00008236284,0.00006380052,0.0002630606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006178794,0.0007137568,0.0005905421,0.00008513565,0.00004722907,0.0007940485,0.0001852665,0.0001122239,0.9934515,0.0004542941,0.0003361794,0.002611875],"study_design_scores_gemma":[0.0007564236,0.006964445,0.05101363,0.0003426892,0.0003983988,0.01163927,0.0005184629,0.003211887,0.9081011,0.001271028,0.01559933,0.0001833994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9710858,0.002157466,0.01020655,0.0007536467,0.0003387645,0.0004000779,0.01011202,0.001466453,0.003479223],"genre_scores_gemma":[0.9150937,0.004802328,0.01944402,0.001140085,0.000145528,0.001565212,0.01432642,0.001045168,0.04243751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007018189,"threshold_uncertainty_score":0.02347815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0384528415026672,"score_gpt":0.3165100086709264,"score_spread":0.2780571671682592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}