{"id":"W3011453881","doi":"10.1111/bjd.19018","title":"Ustekinumab for the treatment of moderate‐to‐severe plaque psoriasis in paediatric patients (≥ 6 to &lt; 12 years of age): efficacy, safety, pharmacokinetic and biomarker results from the open‐label <scp>CADMUS</scp> Jr study","year":2020,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexus Clinical Research (Canada); Memorial University of Newfoundland","funders":"Janssen Research and Development","keywords":"Ustekinumab; Medicine; Psoriasis Area and Severity Index; Psoriasis; Adverse effect; Dermatology Life Quality Index; Dosing; Internal medicine; Discontinuation; Gastroenterology; Dermatology; Infliximab; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001375086,0.0005371686,0.0009932863,0.000210905,0.0001699084,0.0004556387,0.0003221983,0.0005100699,0.001266271],"category_scores_gemma":[0.001034053,0.0002499348,0.0009831851,0.0002351963,0.0004178988,0.000379708,0.0002488782,0.001242288,0.0002643339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004058532,"about_ca_system_score_gemma":0.0006139881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006070244,"about_ca_topic_score_gemma":0.001970247,"domain_scores_codex":[0.9992662,0.0004393468,0.000061682,0.00005550138,0.000125127,0.00005212779],"domain_scores_gemma":[0.9988747,0.0002234323,0.0004827909,0.00005017677,0.00009571515,0.0002730754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3249048,0.03473265,0.168374,0.004811318,0.005862296,0.002468501,0.001167599,0.002516422,0.06119031,0.000311584,0.005155422,0.388505],"study_design_scores_gemma":[0.1541996,0.370223,0.4430885,0.0006018017,0.00290137,0.005066067,0.0003506909,0.001290641,0.01079175,0.0001355442,0.01129385,0.00005727421],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916542,0.007096297,0.0001452778,0.00012732,0.00002394471,0.0002077761,0.0002239824,0.00001085036,0.0005103655],"genre_scores_gemma":[0.9914842,0.00621352,0.0007543597,0.0002623394,0.00009505138,0.0002052274,0.0005305678,0.000007489715,0.0004472879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001375086,"threshold_uncertainty_score":0.007272184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03612339614048511,"score_gpt":0.273350417063129,"score_spread":0.2372270209226439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}