{"id":"W3011453881","doi":"10.1111/bjd.19018","title":"Ustekinumab for the treatment of moderate‐to‐severe plaque psoriasis in paediatric patients (≥ 6 to &lt; 12 years of age): efficacy, safety, pharmacokinetic and biomarker results from the open‐label <scp>CADMUS</scp> Jr study","year":2020,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexus Clinical Research (Canada); Memorial University of Newfoundland","funders":"Janssen Research and Development","keywords":"Ustekinumab; Medicine; Psoriasis Area and Severity Index; Psoriasis; Adverse effect; Dermatology Life Quality Index; Dosing; Internal medicine; Discontinuation; Gastroenterology; Dermatology; Infliximab; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002305315,0.0002173376,0.0008086388,0.0001270167,0.0001279581,0.00003353795,0.0005691755,0.0001638422,0.00001541215],"category_scores_gemma":[0.0005043786,0.0001650105,0.0001261149,0.000294107,0.00009263008,0.00007912442,0.0001712458,0.0001388267,0.00000756218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004251684,"about_ca_system_score_gemma":0.0001097599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004331137,"about_ca_topic_score_gemma":0.0005455077,"domain_scores_codex":[0.9975975,0.0006674138,0.001022941,0.0003131502,0.00008760595,0.0003113654],"domain_scores_gemma":[0.9962288,0.002845201,0.000503665,0.0001967186,0.0001473079,0.00007834997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02559102,0.01015094,0.08706635,0.00005488953,0.006003275,0.001445314,0.0289514,0.0003439025,0.005981589,0.00001905597,0.03959968,0.7947926],"study_design_scores_gemma":[0.1120863,0.004656706,0.8511607,0.0001616968,0.001611257,0.001069495,0.00203167,0.00003347073,0.006433595,0.00005000861,0.02049024,0.0002148772],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892849,0.006455788,0.00004791059,0.0009079695,0.000494364,0.001781103,0.0009825868,0.000005656793,0.00003969025],"genre_scores_gemma":[0.996547,0.002789867,0.0001914347,0.0002269398,0.0000534244,0.00005586826,0.00007308349,0.00002274193,0.00003967421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7945777,"threshold_uncertainty_score":0.6728934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03612339614048511,"score_gpt":0.273350417063129,"score_spread":0.2372270209226439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}