{"id":"W3011481633","doi":"10.7554/elife.49900.sa2","title":"Author response: The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes","year":2020,"lang":"en","type":"peer-review","venue":"","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Repertoire; Biology; clone (Java method); Computational biology; Evolutionary biology; Genetics; Physics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006152595,0.0004434205,0.0006098967,0.0007404076,0.001158741,0.00232547,0.0008282338,0.00496399,0.1136156],"category_scores_gemma":[0.04968675,0.0002672317,0.0004161734,0.0003418547,0.001208899,0.0009685982,0.001446045,0.004379616,0.05108565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001152248,"about_ca_system_score_gemma":0.00249284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008626012,"about_ca_topic_score_gemma":0.00173992,"domain_scores_codex":[0.994076,0.001810165,0.0003242048,0.0006255919,0.002588443,0.0005755665],"domain_scores_gemma":[0.9628039,0.0131607,0.001657932,0.001930055,0.0169781,0.003469285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001681003,0.00001793874,0.0004206179,0.0001858623,0.00001407432,0.0002329539,0.00008019416,0.0000545871,0.001155218,0.001228497,0.971029,0.02541284],"study_design_scores_gemma":[0.00007014259,0.00006498021,0.0008616951,0.00009682253,0.00001200398,0.0004592868,0.000277464,0.0001096133,0.001240058,0.002089239,0.9946995,0.00001919057],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003457228,0.002698899,0.002971318,0.8022315,0.1469471,0.0001906167,0.0009502737,0.0006318933,0.03992134],"genre_scores_gemma":[0.04389081,0.004029509,0.003464218,0.44168,0.06263188,0.0003162014,0.001225958,0.0007257697,0.4420357],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1136156,"threshold_uncertainty_score":0.3800821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1098761402091364,"score_gpt":0.3768235031944047,"score_spread":0.2669473629852683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}