{"id":"W3011487857","doi":"10.3390/cancers12030687","title":"ATM-Deficient Cancers Provide New Opportunities for Precision Oncology","year":2020,"lang":"en","type":"review","venue":"Cancers","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; National Institutes of Health; Alberta Cancer Foundation; Cancer Research Society","keywords":"PARP inhibitor; Cancer research; Poly ADP ribose polymerase; Synthetic lethality; Ataxia-telangiectasia; Cancer; DNA damage; Ovarian cancer; Cytotoxic T cell; Medicine; DNA repair; Polymerase; Gene; Biology; DNA; Internal medicine; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004319244,0.0006600627,0.0008890447,0.001489441,0.0002349648,0.0008594609,0.0005406701,0.0009339952,0.006920728],"category_scores_gemma":[0.000369346,0.0001577606,0.0004334887,0.0009407892,0.0005064858,0.001596036,0.000670654,0.002698295,0.003261029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005332382,"about_ca_system_score_gemma":0.0006061912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004058126,"about_ca_topic_score_gemma":0.001123618,"domain_scores_codex":[0.9998864,0.00002276475,0.00001123596,0.00001992783,0.00004577585,0.00001393098],"domain_scores_gemma":[0.9997918,0.0000954197,0.00002341228,0.00001096911,0.00004994047,0.00002853131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006029583,0.00005886134,0.0001308513,0.006244384,0.0000569736,0.0002945679,0.00003985828,0.0003819838,0.003699642,0.01168075,0.04520479,0.932147],"study_design_scores_gemma":[0.00001011243,0.00005832557,0.0002749175,0.0009153307,0.00002917504,0.001029188,0.0000293044,0.00006022243,0.000319843,0.003171681,0.9940931,0.000008760228],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001517214,0.9955656,0.000424243,0.0008370324,0.000367982,0.000004263128,0.00002235139,0.00002113192,0.002605614],"genre_scores_gemma":[0.001425797,0.9950548,0.0004882287,0.0007480653,0.0004790362,0.000006035309,0.00006147513,0.00000411511,0.001732338],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006920728,"threshold_uncertainty_score":0.02315211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3029223856736641,"score_gpt":0.4471689206659985,"score_spread":0.1442465349923344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}