{"id":"W3011487857","doi":"10.3390/cancers12030687","title":"ATM-Deficient Cancers Provide New Opportunities for Precision Oncology","year":2020,"lang":"en","type":"review","venue":"Cancers","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; National Institutes of Health; Alberta Cancer Foundation; Cancer Research Society","keywords":"PARP inhibitor; Cancer research; Poly ADP ribose polymerase; Synthetic lethality; Ataxia-telangiectasia; Cancer; DNA damage; Ovarian cancer; Cytotoxic T cell; Medicine; DNA repair; Polymerase; Gene; Biology; DNA; Internal medicine; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000262407,0.0006385723,0.002784809,0.0002445524,0.0001211146,0.00003494801,0.0003252206,0.0005320166,0.0005952938],"category_scores_gemma":[0.00016148,0.0005474311,0.0008980929,0.0003860271,0.0002039153,0.00008104693,0.00006437225,0.0005816366,0.0000601549],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.02672389,"about_ca_system_score_gemma":0.05514392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003228984,"about_ca_topic_score_gemma":0.00007097403,"domain_scores_codex":[0.9969691,0.0001171446,0.0009900074,0.0008827306,0.0004526121,0.0005883831],"domain_scores_gemma":[0.9973955,0.00038106,0.0007484673,0.0005885009,0.0001863831,0.0007000532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002465028,0.000007593421,1.428087e-7,0.007786969,0.0002703035,0.00006012924,0.0002018968,0.00002852944,0.000002282689,0.0001265269,0.2305598,0.7607093],"study_design_scores_gemma":[0.00185625,0.0011997,8.063646e-8,0.01552737,0.00141169,0.0001173688,0.0002718561,0.00004641705,0.00002231583,0.00006626274,0.9790079,0.0004727858],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000001276956,0.9800892,0.0009950621,0.001836798,0.002502198,0.0045107,0.0004998825,0.0001808543,0.009384067],"genre_scores_gemma":[0.000001958779,0.9816776,0.001429887,0.002708253,0.002394401,0.001599723,0.0004297728,0.000179342,0.009579051],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7602366,"threshold_uncertainty_score":0.9996977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3029223856736641,"score_gpt":0.4471689206659985,"score_spread":0.1442465349923344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}