{"id":"W3011531441","doi":"10.18632/oncoscience.495","title":"SOCS1: phosphorylation, dimerization and tumor suppression","year":2020,"lang":"en","type":"article","venue":"Oncoscience","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Suppressor of cytokine signaling 1; SOCS3; Suppressor of cytokine signalling; Phosphorylation; Src family kinase; Cancer research; Cytokine; Tyrosine phosphorylation; Cell biology; Signal transduction; Proto-oncogene tyrosine-protein kinase Src; JAK-STAT signaling pathway; Kinase; Suppressor; Tyrosine kinase; Biology; STAT3; Cancer; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004597855,0.00004683361,0.00007171713,0.00002016175,0.0001022686,0.00002225354,0.00003230048,0.00001337617,0.0001681634],"category_scores_gemma":[0.0002721841,0.0000378672,0.00001717265,0.0001874376,0.00005352555,0.0001275332,0.00002364662,0.00006597066,0.00002434947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001229096,"about_ca_system_score_gemma":0.00005208886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001351159,"about_ca_topic_score_gemma":5.004074e-7,"domain_scores_codex":[0.999528,0.000007759699,0.00009187435,0.0001636737,0.0001315544,0.00007714337],"domain_scores_gemma":[0.9997122,0.00002533483,0.00003787874,0.00006360883,0.00004389975,0.0001171172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002376688,0.00002205847,0.00524031,0.00001189266,0.000001320842,0.000004523673,0.000418586,0.00001417846,0.9890816,0.000260829,0.001811817,0.003109091],"study_design_scores_gemma":[0.0007796248,0.0006308812,0.05551724,0.0001300253,0.00003416393,0.00007475248,0.0003001571,0.05320197,0.7797194,0.0001017448,0.1093386,0.0001713518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746103,0.0001259601,0.01309421,0.006885657,0.0002208299,0.0001799352,0.000006678441,0.00008786811,0.004788541],"genre_scores_gemma":[0.9966407,0.00001726767,0.001171868,0.001978289,0.00008336072,0.000003324579,0.000006381293,0.000004659913,0.00009411607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2093622,"threshold_uncertainty_score":0.1841271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02886345491104744,"score_gpt":0.280718217552041,"score_spread":0.2518547626409935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}