{"id":"W3011531441","doi":"10.18632/oncoscience.495","title":"SOCS1: phosphorylation, dimerization and tumor suppression","year":2020,"lang":"en","type":"article","venue":"Oncoscience","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Suppressor of cytokine signaling 1; SOCS3; Suppressor of cytokine signalling; Phosphorylation; Src family kinase; Cancer research; Cytokine; Tyrosine phosphorylation; Cell biology; Signal transduction; Proto-oncogene tyrosine-protein kinase Src; JAK-STAT signaling pathway; Kinase; Suppressor; Tyrosine kinase; Biology; STAT3; Cancer; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001459547,0.0003279355,0.0001585816,0.0002186132,0.0002113017,0.0003027629,0.0001042168,0.0001520713,0.002898661],"category_scores_gemma":[0.00009852624,0.00006767041,0.000201152,0.0001629773,0.0002204497,0.0001698005,0.0002509395,0.0003281482,0.0003938768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003419965,"about_ca_system_score_gemma":0.0002153154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002823629,"about_ca_topic_score_gemma":0.0003354546,"domain_scores_codex":[0.999894,0.00001766305,0.000006697849,0.00002043801,0.00002180673,0.00003934514],"domain_scores_gemma":[0.9999247,0.000004753048,0.00003205602,0.000004213216,0.000007594118,0.00002663663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004919054,0.00006646565,0.002234663,0.0003707863,0.00002570149,0.0003468898,0.0000769493,0.0003613063,0.963825,0.0018795,0.002167744,0.028153],"study_design_scores_gemma":[0.00009821015,0.001124235,0.05864668,0.00005656859,0.0000610609,0.005420303,0.0002032239,0.003177341,0.8637757,0.001815536,0.06558821,0.00003290636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9509467,0.03215409,0.003660367,0.001113173,0.0002495333,0.00005896678,0.0009732149,0.0002636381,0.01058035],"genre_scores_gemma":[0.9926158,0.002858629,0.0004953769,0.0001424128,0.00004406033,0.00001721381,0.0004679582,0.00000998475,0.003348623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002898661,"threshold_uncertainty_score":0.00969702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02886345491104744,"score_gpt":0.280718217552041,"score_spread":0.2518547626409935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}