{"id":"W3011535324","doi":"10.1126/sciadv.aay3324","title":"YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Tokyo Medical and Dental University; Japan Society for the Promotion of Science; Daiichi-Sankyo; Japan Agency for Medical Research and Development; Advanced Medical Research Foundation","keywords":"YAP1; Basal cell; Cancer research; Medicine; Cell; Biology; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001415231,0.0002197634,0.0001677572,0.0003055939,0.0001758517,0.0002127281,0.00008379659,0.0001411958,0.001512102],"category_scores_gemma":[0.00007647714,0.0001518286,0.0001407102,0.0001566043,0.0001893917,0.0001552288,0.0002367118,0.0004576914,0.000333835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002802951,"about_ca_system_score_gemma":0.0002759642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008894993,"about_ca_topic_score_gemma":0.001555922,"domain_scores_codex":[0.9999299,0.000006770132,0.000004859788,0.00001462802,0.00002793496,0.00001591067],"domain_scores_gemma":[0.9999584,0.00000522868,0.00001114226,0.00000610217,0.00000699457,0.00001213522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000232544,0.000008804753,0.0002797658,0.00001268101,0.000002100216,0.00002877394,0.000004943877,0.00002856979,0.9979792,0.0000988321,0.00005136426,0.001481663],"study_design_scores_gemma":[0.00000489717,0.0002019815,0.009305896,0.000003551098,0.000009873761,0.0004203701,0.00002166374,0.0004178869,0.9845015,0.00006416887,0.005043722,0.000004396046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872677,0.002972275,0.005160197,0.0002036756,0.0000387238,0.00005248521,0.0007755295,0.0001489607,0.003380429],"genre_scores_gemma":[0.9904134,0.002050485,0.001566774,0.00003766735,0.00001267325,0.00003610094,0.0005619579,0.00002246581,0.005298553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001512102,"threshold_uncertainty_score":0.005058527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102771154132531,"score_gpt":0.2600612401904138,"score_spread":0.2490335286490885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}