{"id":"W3011535324","doi":"10.1126/sciadv.aay3324","title":"YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Tokyo Medical and Dental University; Japan Society for the Promotion of Science; Daiichi-Sankyo; Japan Agency for Medical Research and Development; Advanced Medical Research Foundation","keywords":"YAP1; Basal cell; Cancer research; Medicine; Cell; Biology; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000107277,0.00005629588,0.00007179222,0.00001223512,0.00007506883,0.000005940701,0.0002175525,0.00002413856,0.000003273861],"category_scores_gemma":[0.00004894784,0.00003525026,0.00003082586,0.0001584032,0.0005411473,0.000006754588,0.0001143221,0.00003233062,5.761875e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002092401,"about_ca_system_score_gemma":0.00009219498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006808817,"about_ca_topic_score_gemma":0.000002134793,"domain_scores_codex":[0.9993995,0.00001825552,0.00009544307,0.0002033425,0.0001719486,0.0001114958],"domain_scores_gemma":[0.9996665,0.000004442277,0.0000804292,0.000134848,0.00006158036,0.00005220501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001719752,0.00001619395,0.02446381,0.00002316963,5.546192e-7,4.158815e-7,0.0003050963,0.00002526275,0.9710845,0.000002838803,0.00001777354,0.004043143],"study_design_scores_gemma":[0.0001474275,0.0003433044,0.005117919,0.000008422111,0.000004373294,0.0000018195,0.0001722946,0.00007396132,0.9925528,0.0000297706,0.001499398,0.00004846976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979249,0.001475659,0.00005845093,0.0002251702,0.00004508079,0.0000761877,0.00001517227,0.000002177409,0.0001771927],"genre_scores_gemma":[0.9990607,0.00001684376,0.0007052558,0.0001611131,0.00001302253,0.000001843446,0.000001102524,0.000002701309,0.00003742261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02146829,"threshold_uncertainty_score":0.199388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102771154132531,"score_gpt":0.2600612401904138,"score_spread":0.2490335286490885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}