{"id":"W3011568629","doi":"10.1016/j.annonc.2020.01.028","title":"19O A phase Ib trial of CFI-402257 in combination with weekly paclitaxel in patients with advanced HER2-negative (HER2-) breast cancer (aBC)","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; Ottawa Hospital; Canadian Partnership Against Cancer; Princess Margaret Cancer Centre","funders":"Ontario Institute for Cancer Research; Canadian Cancer Society; Stand Up To Cancer Canada; Government of Ontario","keywords":"Medicine; Neutropenia; Internal medicine; Taxane; Breast cancer; Adverse effect; Nausea; Tolerability; Febrile neutropenia; Paclitaxel; Oncology; Cancer; Metastatic breast cancer; Chemotherapy; Response Evaluation Criteria in Solid Tumors; Gastroenterology; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005833721,0.0009676716,0.00148171,0.000575867,0.0004117896,0.0009701891,0.0006499555,0.001228025,0.009923161],"category_scores_gemma":[0.0004498707,0.0003865359,0.001045015,0.0004287834,0.0005397095,0.0005099623,0.0003013375,0.002772124,0.001781956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007170246,"about_ca_system_score_gemma":0.001518384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002339727,"about_ca_topic_score_gemma":0.006774646,"domain_scores_codex":[0.9998013,0.00006218471,0.000009433047,0.00002871108,0.00001629808,0.00008198486],"domain_scores_gemma":[0.9997253,0.00003792156,0.00002886263,0.00001699979,0.00001366084,0.0001772727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5407079,0.05297782,0.007819233,0.001360586,0.00209173,0.0006813642,0.0002680437,0.00338842,0.05663254,0.001234215,0.02277109,0.3100671],"study_design_scores_gemma":[0.6317983,0.3325754,0.0117384,0.0001179996,0.0006992937,0.0005729502,0.00008342138,0.001643214,0.005818882,0.0004244802,0.01447802,0.00004970868],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746242,0.004009605,0.0007215975,0.001684296,0.0005541139,0.003190783,0.003608486,0.000308445,0.01129855],"genre_scores_gemma":[0.9649844,0.004819703,0.002820412,0.002626879,0.0004452613,0.002685799,0.006563501,0.0000804086,0.01497365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009923161,"threshold_uncertainty_score":0.03319627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05386763053986506,"score_gpt":0.4132210440111539,"score_spread":0.3593534134712889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}