{"id":"W3011641153","doi":"10.1101/2020.03.17.989699","title":"Vaccine Elicitation of HIV Broadly Neutralizing Antibodies from Engineered B cells","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institutes of Health; Bill and Melinda Gates Foundation","keywords":"Somatic hypermutation; Antibody; Biology; Virology; Genetically engineered; B cell; Immunization; Viremia; Neutralizing antibody; Immunology; Transduction (biophysics); Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001848184,0.0004941366,0.0007958537,0.0002387737,0.0001136306,0.00005075957,0.0004686667,0.0005746504,0.000235432],"category_scores_gemma":[0.0001421937,0.0004929843,0.000206809,0.000260736,0.00009373707,0.00009022329,0.0003651304,0.0007617426,0.0009236714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001147857,"about_ca_system_score_gemma":0.0003006016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003297911,"about_ca_topic_score_gemma":0.000004607706,"domain_scores_codex":[0.9977556,0.0002286117,0.0005852099,0.0007835294,0.0001117934,0.0005352615],"domain_scores_gemma":[0.9982623,0.0001785335,0.0003442887,0.0007799803,0.000324371,0.0001105477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001234187,0.0001658125,0.00467754,0.0002247516,0.0009091656,0.00003974132,0.00005077903,0.0000487416,0.991226,0.0001341863,0.002395825,0.000004074986],"study_design_scores_gemma":[0.001278821,0.00009439611,0.08787124,0.0002429011,0.0001758922,7.860582e-9,0.000007955059,0.00002928808,0.9060664,0.000002763499,0.003856784,0.0003735858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870524,0.006539165,0.0008067787,0.0004319915,0.0009220293,0.000661929,0.003303289,0.0002721833,0.00001023193],"genre_scores_gemma":[0.9970996,0.0008145897,0.001704203,0.00005641777,0.0001343009,0.00007567499,0.00002410823,0.00007879415,0.00001234292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08515959,"threshold_uncertainty_score":0.9998542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01602771263375862,"score_gpt":0.2316976662225202,"score_spread":0.2156699535887616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}