{"id":"W3011641153","doi":"10.1101/2020.03.17.989699","title":"Vaccine Elicitation of HIV Broadly Neutralizing Antibodies from Engineered B cells","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institutes of Health; Bill and Melinda Gates Foundation","keywords":"Somatic hypermutation; Antibody; Biology; Virology; Genetically engineered; B cell; Immunization; Viremia; Neutralizing antibody; Immunology; Transduction (biophysics); Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002350161,0.000526154,0.000216122,0.0002790241,0.0001440659,0.0003470262,0.0001757303,0.0004843996,0.001779625],"category_scores_gemma":[0.0001737413,0.0001926005,0.000226872,0.0001327684,0.000175195,0.0001708941,0.000398571,0.0008167883,0.0009817961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002156435,"about_ca_system_score_gemma":0.0001499142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002040218,"about_ca_topic_score_gemma":0.000232955,"domain_scores_codex":[0.9998728,0.00002184334,0.000008743525,0.00002654432,0.00003865326,0.00003149172],"domain_scores_gemma":[0.9999288,0.00002051156,0.00001444344,0.00001010423,0.00000994735,0.00001621589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000294127,0.00002715363,0.00005271359,0.0000349119,0.000004233892,0.00002483402,0.00001068554,0.0001336616,0.9976835,0.0002500075,0.0001144597,0.00163446],"study_design_scores_gemma":[0.00003866194,0.0002095574,0.0004897046,0.00001043237,0.00001200987,0.0001703026,0.000009217657,0.001043432,0.9917651,0.0001533069,0.00609553,0.000002685122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9341691,0.003930278,0.05153851,0.0004169797,0.0002517705,0.0002815804,0.001001251,0.0004609033,0.007949509],"genre_scores_gemma":[0.9489253,0.002742314,0.03457953,0.0004939953,0.00005841249,0.0001954374,0.001717184,0.0001429736,0.01114484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001779625,"threshold_uncertainty_score":0.005953431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01602771263375862,"score_gpt":0.2316976662225202,"score_spread":0.2156699535887616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}