{"id":"W3011660632","doi":"10.1126/science.aax0902","title":"Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling","year":2020,"lang":"en","type":"article","venue":"Science","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":301,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Terry Fox Research Institute; Krembil Foundation; Canadian Cancer Society; Human Frontier Science Program","keywords":"Notch signaling pathway; Head and neck; Cancer research; Mutation; Cell; Head and neck squamous-cell carcinoma; Biology; Signal transduction; Medicine; Genetics; Head and neck cancer; Gene; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003007422,0.0003435652,0.0002679491,0.000463007,0.0003932255,0.0009951139,0.0002733566,0.0006241561,0.002659067],"category_scores_gemma":[0.0004210925,0.0002923766,0.0002155113,0.0002319415,0.0005093067,0.0003441446,0.0005108343,0.001321393,0.001176561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004639602,"about_ca_system_score_gemma":0.0003825768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004687593,"about_ca_topic_score_gemma":0.001132056,"domain_scores_codex":[0.9997597,0.00001943977,0.00001484629,0.00004525658,0.0001265192,0.00003412883],"domain_scores_gemma":[0.999815,0.00004203058,0.00004309888,0.00001693576,0.00003750496,0.00004536344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000994657,0.0001343577,0.02256445,0.0004924835,0.0001583692,0.004776766,0.0003863143,0.001061057,0.6623026,0.01889103,0.06939755,0.2188404],"study_design_scores_gemma":[0.0001302669,0.0004072902,0.07375833,0.0002086746,0.0002714437,0.0189866,0.0006090847,0.004625747,0.4667876,0.01383868,0.4203187,0.00005773441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8078659,0.05370443,0.01999621,0.03678112,0.005897367,0.0001417541,0.002907502,0.002060539,0.07064527],"genre_scores_gemma":[0.9456543,0.02467628,0.00254343,0.004390446,0.001334042,0.00003339155,0.0008421894,0.0001272625,0.02039864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002659067,"threshold_uncertainty_score":0.008895397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02213814038376043,"score_gpt":0.2598658824951172,"score_spread":0.2377277421113568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}