{"id":"W3011691697","doi":"10.1016/j.jpha.2020.03.007","title":"Challenges for cysteamine stabilization, quantification, and biological effects improvement","year":2020,"lang":"en","type":"review","venue":"Journal of Pharmaceutical Analysis","topic":"Biomedical Research and Pathophysiology","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Université Libanaise; Agence Universitaire de la Francophonie","keywords":"Cysteamine; Derivatization; Chemistry; Combinatorial chemistry; Nanotechnology; Chromatography; Organic chemistry; Materials science; High-performance liquid chromatography","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001053226,0.0002759652,0.002808081,0.0005013223,0.00005010652,0.00001818108,0.0001804701,0.0003135451,0.00008164361],"category_scores_gemma":[0.002422439,0.0001550479,0.001207429,0.0008507625,0.0002146578,0.00003382977,0.00007289857,0.0006006554,0.000006787023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008270817,"about_ca_system_score_gemma":0.000287418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":5.550648e-7,"about_ca_topic_score_gemma":5.546287e-7,"domain_scores_codex":[0.9974362,0.0003344091,0.001141321,0.0003810897,0.0004116892,0.0002953047],"domain_scores_gemma":[0.9963343,0.001651887,0.0005528384,0.0001753674,0.0004648275,0.0008207635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000194816,0.0002484816,0.00001315142,0.01924168,0.005157023,0.00006526213,0.00001561187,1.421756e-7,0.0003743031,0.0001753656,0.0001940451,0.9743201],"study_design_scores_gemma":[0.001029621,0.002247527,0.00008750132,0.001176332,0.02001175,0.00007793718,0.00001705573,0.000564052,0.0000498576,0.0001306944,0.9744553,0.0001524051],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003735183,0.9894676,0.007247117,0.002342019,0.00008167847,0.0007587305,0.00003688972,0.000009479953,0.00001919297],"genre_scores_gemma":[0.000773253,0.9975056,0.000722758,0.0002122757,0.0005800178,0.00004882825,0.0001110923,0.00001814008,0.00002805837],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9742612,"threshold_uncertainty_score":0.632267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2599980389762622,"score_gpt":0.4941522658608493,"score_spread":0.2341542268845871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}