{"id":"W3011699337","doi":"10.1093/cvr/cvaa067","title":"Sectm1a deficiency aggravates inflammation-triggered cardiac dysfunction through disruption of LXRα signalling in macrophages","year":2020,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute","funders":"National Institute of General Medical Sciences; National Institutes of Health; American Heart Association","keywords":"Inflammation; Proinflammatory cytokine; Lipopolysaccharide; Liver X receptor; Endocrinology; Internal medicine; Macrophage; Medicine; Cardiac function curve; Immunology; Biology; Heart failure; Transcription factor; Nuclear receptor; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001326163,0.0001518671,0.0003228144,0.0001125405,0.0001209273,0.00003566783,0.0002422502,0.0001744347,0.00001749868],"category_scores_gemma":[0.0004446309,0.000152871,0.0005077638,0.0006586574,0.00015507,0.00002090319,0.0001565612,0.0002646982,0.00002994431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003060037,"about_ca_system_score_gemma":0.0001110528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000104105,"about_ca_topic_score_gemma":0.000006293994,"domain_scores_codex":[0.9977277,0.0004794415,0.0003422632,0.0004481837,0.0006056814,0.0003967372],"domain_scores_gemma":[0.9990748,0.00003043441,0.00005414021,0.0004273829,0.0003577532,0.00005545683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001542879,0.0000262546,0.002003284,0.000187649,0.0003292421,0.000009854148,0.0008079322,0.005890459,0.9784929,0.0001044879,0.0001544129,0.0118392],"study_design_scores_gemma":[0.0009716398,0.0003123759,0.002716492,0.00004327855,0.00004580844,0.000002519055,0.001660733,0.000290308,0.9819299,0.0001691789,0.01161793,0.0002398183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699842,0.02597003,0.002226044,0.0001133713,0.00008586772,0.0004637725,0.000009073475,0.00001300428,0.001134648],"genre_scores_gemma":[0.995395,0.003957319,0.0001136471,0.00001008834,0.0002320671,0.00005821635,0.0001686533,0.00002802744,0.00003698844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0254108,"threshold_uncertainty_score":0.62339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04170699689661066,"score_gpt":0.2989422725424588,"score_spread":0.2572352756458481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}