{"id":"W3011703432","doi":"10.1039/d0mt00023j","title":"Metallothionein Cd4S11 cluster formation dominates in the protection of carbonic anhydrase","year":2020,"lang":"en","type":"article","venue":"Metallomics","topic":"Trace Elements in Health","field":"Nursing","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Carbonic anhydrase; Carbonic anhydrase II; Metal; Metallothionein; Electrospray ionization; Metalloprotein; Zinc; Bioinorganic chemistry; Stereochemistry; Inorganic chemistry; Enzyme; Crystallography; Biochemistry; Mass spectrometry; Organic chemistry; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008976351,0.0001285914,0.0002278742,0.00009190378,0.00006176334,0.00002701201,0.000229085,0.00007640919,0.00001820323],"category_scores_gemma":[0.0002292367,0.00009880468,0.00007883864,0.0003407993,0.0000411354,0.0003140348,0.000035016,0.000282516,0.00001679374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001035383,"about_ca_system_score_gemma":0.0000198073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001645387,"about_ca_topic_score_gemma":0.0002131189,"domain_scores_codex":[0.9984869,0.0003430017,0.0004938164,0.0001812921,0.0002736961,0.0002212564],"domain_scores_gemma":[0.9993731,0.00009765061,0.0002272714,0.0002234491,0.00003849625,0.00004008053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008010671,0.002222525,0.007095897,0.005506336,0.0004159976,0.00002826414,0.1863461,0.02171903,0.5883698,0.008770461,0.002245777,0.1692691],"study_design_scores_gemma":[0.01262725,0.003828365,0.0237714,0.000300621,0.0007893957,0.00007670886,0.01183583,0.4135994,0.4911154,0.006589002,0.03406276,0.001403921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848206,0.0001776458,0.002036462,0.0110815,0.0003080336,0.001254471,0.000006671025,0.00004278872,0.0002718193],"genre_scores_gemma":[0.996749,0.00001242494,0.001587175,0.001467908,0.00007586816,0.00006904113,0.00001108936,0.00002002841,0.000007419567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3918804,"threshold_uncertainty_score":0.4029138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04470618413776187,"score_gpt":0.2788551454813214,"score_spread":0.2341489613435595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}