{"id":"W3011736930","doi":"10.1128/mbio.00019-20","title":"<i>In Vivo</i> Targeting of Clostridioides difficile Using Phage-Delivered CRISPR-Cas3 Antimicrobials","year":2020,"lang":"en","type":"article","venue":"mBio","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":218,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Cancer Institute","keywords":"CRISPR; Lytic cycle; Phage therapy; Microbiology; Biology; Bacteriophage; Clostridium difficile; Antimicrobial; Clostridioides; Pathogen; Antibiotic resistance; Virology; Lysogen; Antibiotics; Genetics; Virus; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002907382,0.0004081524,0.0002285683,0.0002030238,0.000194036,0.000464815,0.0002520074,0.0004444132,0.003886448],"category_scores_gemma":[0.0002389719,0.0001330171,0.0002593095,0.0001131818,0.0003217407,0.0001830343,0.0002760644,0.0006713831,0.000891311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003103275,"about_ca_system_score_gemma":0.0003143756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009793824,"about_ca_topic_score_gemma":0.001320993,"domain_scores_codex":[0.9997293,0.00004446623,0.00002043507,0.00006202358,0.00008549767,0.0000583223],"domain_scores_gemma":[0.999871,0.00001921651,0.00004392642,0.00002044659,0.00001555741,0.00002976017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001167746,0.00003000404,0.0001553817,0.00007100219,0.00000588559,0.00004740183,0.00001547931,0.0001489345,0.9940995,0.000640066,0.001254974,0.003414581],"study_design_scores_gemma":[0.00002188165,0.0002934413,0.001093904,0.00001592241,0.00001038065,0.0003261226,0.00001666018,0.001282547,0.9796022,0.0001455856,0.01718141,0.00001003831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7556394,0.008297816,0.1536652,0.003333705,0.001824144,0.0006272328,0.005982041,0.006574049,0.06405639],"genre_scores_gemma":[0.9399379,0.002303638,0.03344869,0.000979743,0.00009214649,0.0002605824,0.00198494,0.0003806133,0.02061196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003886448,"threshold_uncertainty_score":0.0130015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04334052852355734,"score_gpt":0.3108500068984913,"score_spread":0.2675094783749339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}