{"id":"W3011759407","doi":"10.1021/acsomega.0c00205","title":"Homology Modeling of Human Uridine-5′-diphosphate-glucuronosyltransferase 1A6 Reveals Insights into Factors Influencing Substrate and Cosubstrate Binding","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Uridine diphosphate; Biochemistry; Cofactor; Glucuronidation; Glycosyltransferase; Homology modeling; Enzyme; Glucuronosyltransferase; Uridine; Chemistry; Binding site; Docking (animal); Substrate (aquarium); Stereochemistry; Biology; Gene; RNA; Microsome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001461174,0.0002192903,0.0002786866,0.00009995334,0.0001734416,0.00003962199,0.0002219231,0.0001935796,0.00001015111],"category_scores_gemma":[0.00009634975,0.0002089222,0.00006813705,0.0002206455,0.0001185614,0.0000214172,0.0001020554,0.000197011,0.000005914514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000142971,"about_ca_system_score_gemma":0.00007780264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001245653,"about_ca_topic_score_gemma":0.00006937024,"domain_scores_codex":[0.9985628,0.00008510843,0.0004086513,0.0004505973,0.0001837044,0.0003091886],"domain_scores_gemma":[0.9992832,0.00001519659,0.0000903895,0.000236017,0.0001411593,0.0002340586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000611771,0.0000230539,0.01119582,0.00009196711,0.00004883524,0.00001101936,0.0008289749,0.000637713,0.9866911,0.000266451,0.00001998748,0.0001239389],"study_design_scores_gemma":[0.0008609961,0.0005619703,0.002884061,0.00002609327,0.00001895739,0.000004065015,0.0003935444,0.001186197,0.9933343,0.0002637715,0.0001903044,0.000275765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978159,0.001103927,0.0003963454,0.0001361471,0.00003186597,0.000280269,0.00001308477,0.00002130176,0.0002011447],"genre_scores_gemma":[0.9991424,0.0003600696,0.0001035258,0.0001192301,0.00006000433,0.00001374792,0.0001322529,0.00002996221,0.00003880874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008311761,"threshold_uncertainty_score":0.8519599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02965906395998802,"score_gpt":0.2777392028177822,"score_spread":0.2480801388577942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}