{"id":"W3011759407","doi":"10.1021/acsomega.0c00205","title":"Homology Modeling of Human Uridine-5′-diphosphate-glucuronosyltransferase 1A6 Reveals Insights into Factors Influencing Substrate and Cosubstrate Binding","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Uridine diphosphate; Biochemistry; Cofactor; Glucuronidation; Glycosyltransferase; Homology modeling; Enzyme; Glucuronosyltransferase; Uridine; Chemistry; Binding site; Docking (animal); Substrate (aquarium); Stereochemistry; Biology; Gene; RNA; Microsome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002176303,0.0007750848,0.0008650965,0.0002617792,0.0004508486,0.0007122841,0.0005315446,0.0006745002,0.003460578],"category_scores_gemma":[0.000347037,0.0002706652,0.0006642115,0.0003041728,0.0002206017,0.0003394517,0.0002734202,0.0005532631,0.0004687923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008037427,"about_ca_system_score_gemma":0.001034293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0101785,"about_ca_topic_score_gemma":0.008543801,"domain_scores_codex":[0.9998757,0.00003249756,0.00000406157,0.00002550788,0.00003320192,0.00002895575],"domain_scores_gemma":[0.9999169,0.00003193902,0.00001412396,0.000004256121,0.00001244796,0.00002037346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0009358471,0.0003148369,0.007007611,0.0002781119,0.0001412627,0.0007438868,0.0002078688,0.8938468,0.07734923,0.005978642,0.001430336,0.01176558],"study_design_scores_gemma":[0.00007374673,0.0002038243,0.001196172,0.00001535548,0.00003866941,0.00008411209,0.0001025576,0.9865225,0.009171949,0.0006351857,0.001940781,0.00001512615],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9740536,0.0008715265,0.01811079,0.0002777812,0.00002468641,0.0000382742,0.0009099621,0.0004304563,0.005282865],"genre_scores_gemma":[0.9800025,0.001020283,0.01541547,0.00004838403,0.000006270026,0.0000437112,0.001749733,0.00009948752,0.001614147],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0101785,"threshold_uncertainty_score":0.02023852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02965906395998802,"score_gpt":0.2777392028177822,"score_spread":0.2480801388577942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}