{"id":"W3011797989","doi":"10.1126/sciadv.aax7945","title":"Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Knut och Alice Wallenbergs Stiftelse; Cancerföreningen i Stockholm; Vetenskapsrådet; Karolinska Institutet; Svenska Sällskapet för Medicinsk Forskning; Cancerfonden","keywords":"STAT3; Cancer; Cancer research; Programmed cell death; Block (permutation group theory); Apoptosis; Chemistry; Biology; Medicine; Cell biology; Signal transduction; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001649127,0.0003946904,0.0002424475,0.0002079249,0.0001198908,0.0001807735,0.0002422523,0.000201002,0.002475829],"category_scores_gemma":[0.0000946212,0.0001051578,0.0003783913,0.0001749916,0.0001819928,0.0001529149,0.000151717,0.0008415001,0.0004231957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002421105,"about_ca_system_score_gemma":0.0002563904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003218376,"about_ca_topic_score_gemma":0.001310929,"domain_scores_codex":[0.9998618,0.00002717645,0.00001064282,0.00002587491,0.00003763625,0.00003687561],"domain_scores_gemma":[0.9999521,0.000009305669,0.00001782881,0.000005478905,0.000006274723,0.00000890414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002197338,0.0001358425,0.0001756841,0.0001874259,0.00001927906,0.00006451129,0.00001934333,0.0005029586,0.9889776,0.0005301413,0.0003156285,0.008851809],"study_design_scores_gemma":[0.00007213035,0.001597844,0.001039945,0.00001445637,0.00001948109,0.0002080635,0.00001507056,0.0009771027,0.9907839,0.00009302502,0.005170847,0.000008082334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9454015,0.02026068,0.02203117,0.000485624,0.0001580112,0.0003142481,0.001243544,0.0004254261,0.009679884],"genre_scores_gemma":[0.978246,0.007808026,0.007797353,0.0001446032,0.00002268014,0.00009126187,0.0008597581,0.00003289864,0.004997496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002475829,"threshold_uncertainty_score":0.008282483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03657068288001571,"score_gpt":0.3233190051579416,"score_spread":0.2867483222779259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}