{"id":"W3011797989","doi":"10.1126/sciadv.aax7945","title":"Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Knut och Alice Wallenbergs Stiftelse; Cancerföreningen i Stockholm; Vetenskapsrådet; Karolinska Institutet; Svenska Sällskapet för Medicinsk Forskning; Cancerfonden","keywords":"STAT3; Cancer; Cancer research; Programmed cell death; Block (permutation group theory); Apoptosis; Chemistry; Biology; Medicine; Cell biology; Signal transduction; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000981043,0.00009406605,0.0001389445,0.00004582351,0.0002204473,0.0000380133,0.00008780169,0.00002047812,0.0001033313],"category_scores_gemma":[0.00008052769,0.00007608163,0.0000301574,0.0004270158,0.0002073786,0.0008514403,0.00005677985,0.0001460076,0.00001100757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000718148,"about_ca_system_score_gemma":0.000268535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002973148,"about_ca_topic_score_gemma":0.00005811211,"domain_scores_codex":[0.9990704,0.000008346268,0.00009735093,0.0003348657,0.0002700605,0.0002189664],"domain_scores_gemma":[0.9994865,0.00003141722,0.00006164066,0.0001008448,0.00008332234,0.0002362564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000402583,0.00004095958,0.005690078,0.00003527229,0.000003022583,0.000005144554,0.0005620886,0.00005849891,0.9826962,0.00001690612,0.000246683,0.01060494],"study_design_scores_gemma":[0.0003638114,0.0003118286,0.005428231,0.00006019952,0.00002231849,0.000009037251,0.0007251015,0.0004183108,0.9665456,0.00002482855,0.02597599,0.0001147219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928623,0.001033411,0.00005608984,0.002119616,0.0002867701,0.0001300307,0.00001261846,0.00004336718,0.003455841],"genre_scores_gemma":[0.9981102,0.0002543995,0.000671477,0.0005978703,0.0001664804,0.00000775861,5.955216e-7,0.000006098328,0.0001850627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0257293,"threshold_uncertainty_score":0.3102519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03657068288001571,"score_gpt":0.3233190051579416,"score_spread":0.2867483222779259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}