{"id":"W3011896977","doi":"10.1128/msphere.00143-20","title":"Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates","year":2020,"lang":"en","type":"article","venue":"mSphere","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; UK Research and Innovation; Queen's University Belfast; Directorate for Biological Sciences; Royal Society; Queen's University; Department for Employment and Learning, Northern Ireland","keywords":"Colistin; Escherichia coli; Biology; Microbiology; Lipid A; Plasmid; Bacteria; MCR-1; Drug resistance; Multiple drug resistance; Enterobacteriaceae; Gene; Genetics; Antibiotics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001702841,0.0001388149,0.0002005821,0.00001125347,0.00004156757,0.0000155793,0.0002704999,0.00007942988,0.00002582601],"category_scores_gemma":[0.0001149396,0.0001092812,0.00003929125,0.0003374658,0.0001048148,0.000004611965,0.00003603516,0.000113009,0.000002565657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002106344,"about_ca_system_score_gemma":0.0000950702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000112578,"about_ca_topic_score_gemma":0.003523287,"domain_scores_codex":[0.9989014,0.0001642851,0.000325617,0.0002691853,0.0001433865,0.0001961555],"domain_scores_gemma":[0.9994642,0.00004253761,0.0001785908,0.0002065657,0.0000685774,0.0000394955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000892722,0.0003986404,0.4017095,0.0002943088,0.0001345078,0.00009311611,0.001344571,0.001725226,0.5904741,0.0006557636,0.002200774,0.00007675732],"study_design_scores_gemma":[0.003783545,0.0006052117,0.9142755,0.000918837,0.00009294668,0.000006680276,0.01142362,0.001871979,0.06415152,0.00004429521,0.002115496,0.0007104053],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970536,0.0003412397,0.0001553379,0.0002433676,0.00003409222,0.0002791639,0.00005646148,0.000009260145,0.001827464],"genre_scores_gemma":[0.9988272,0.00001864015,0.0008255779,0.00009009941,0.00003672199,0.00001860608,0.00008133989,0.00001617709,0.00008566146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5263226,"threshold_uncertainty_score":0.4456359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01050016315416541,"score_gpt":0.2317974983719724,"score_spread":0.221297335217807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}