{"id":"W3011896977","doi":"10.1128/msphere.00143-20","title":"Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates","year":2020,"lang":"en","type":"article","venue":"mSphere","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; UK Research and Innovation; Queen's University Belfast; Directorate for Biological Sciences; Royal Society; Queen's University; Department for Employment and Learning, Northern Ireland","keywords":"Colistin; Escherichia coli; Biology; Microbiology; Lipid A; Plasmid; Bacteria; MCR-1; Drug resistance; Multiple drug resistance; Enterobacteriaceae; Gene; Genetics; Antibiotics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001633262,0.000278813,0.00029639,0.0006999333,0.0001924588,0.0003415258,0.0002108581,0.0003691871,0.000829722],"category_scores_gemma":[0.0008484918,0.0001534921,0.0002388658,0.0005024361,0.0002934168,0.0001170249,0.0002590575,0.0003793909,0.0002297046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001366975,"about_ca_system_score_gemma":0.0001505479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007275143,"about_ca_topic_score_gemma":0.0008161219,"domain_scores_codex":[0.9996032,0.00006703341,0.00005514939,0.00009614188,0.0001135344,0.00006493898],"domain_scores_gemma":[0.999353,0.0001821149,0.0001804879,0.00009368571,0.0001060898,0.00008457965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002749038,0.0001199507,0.04251455,0.00004888398,0.00003664357,0.001254896,0.0001352778,0.00009341864,0.9517065,0.00009353792,0.00004001149,0.003681538],"study_design_scores_gemma":[0.00002773298,0.001314258,0.4500314,0.00002393102,0.0001459869,0.02040252,0.0006228729,0.00149439,0.5243053,0.0001417042,0.001457465,0.00003237553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989265,0.00009702575,0.0005375271,0.00001909687,0.00000362524,0.00001051207,0.0001183715,0.00001154219,0.0002759434],"genre_scores_gemma":[0.9991348,0.00004918497,0.0004459407,0.00001612385,0.000002438454,0.000005696392,0.0001767994,0.000005803683,0.0001632729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000829722,"threshold_uncertainty_score":0.002775729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01050016315416541,"score_gpt":0.2317974983719724,"score_spread":0.221297335217807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}