{"id":"W3011974553","doi":"10.1016/j.bbrc.2020.03.062","title":"FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus","year":2020,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"FKBP; Calcineurin; Aspergillus fumigatus; In vivo; Mutant; Biology; Plasma protein binding; Dimer; Fungal protein; Chemistry; Cell biology; Biochemistry; Microbiology; Transplantation; Genetics; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001434061,0.0002882251,0.0002330927,0.0002635779,0.0003106848,0.0002632155,0.0002947713,0.0004567796,0.003447427],"category_scores_gemma":[0.0002157434,0.0002201871,0.000207828,0.0001956488,0.0003347286,0.0001327093,0.0002116207,0.0004945617,0.0007411364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004070705,"about_ca_system_score_gemma":0.0002522805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00342394,"about_ca_topic_score_gemma":0.005106164,"domain_scores_codex":[0.9996884,0.00007073089,0.00004171627,0.00005240227,0.00007259034,0.00007419196],"domain_scores_gemma":[0.9997973,0.0000428054,0.00004861714,0.00002209194,0.00001655381,0.00007263371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001852441,0.00004318013,0.0001504599,0.00001100858,0.000005837385,0.00005841408,0.000008584542,0.0001143193,0.9989058,0.00009007928,0.00005618764,0.0003708909],"study_design_scores_gemma":[0.00005113882,0.0002401121,0.009445685,0.000007865267,0.00002781302,0.0004626663,0.00005524158,0.00169269,0.9866239,0.00008655048,0.001293055,0.00001335734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978691,0.0002381451,0.000524266,0.00008464363,0.00003421562,0.000008023499,0.0002679502,0.00005534002,0.0009182408],"genre_scores_gemma":[0.9985103,0.00007597539,0.0003610411,0.00004984859,0.000003577409,0.000005985938,0.0001454329,0.0000162746,0.0008316043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003447427,"threshold_uncertainty_score":0.01153272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06134863285291346,"score_gpt":0.3599375714168602,"score_spread":0.2985889385639467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}