{"id":"W3011984489","doi":"10.1124/dmd.119.089714","title":"Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function","year":2020,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Medical Research Council; National Health and Medical Research Council; University of British Columbia","keywords":"Sulfotransferase; Immunoprecipitation; Dopamine; Cytosol; Biochemistry; Biology; HEK 293 cells; Cell biology; RNA interference; Sulfation; Enzyme; Gene; RNA; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008321318,0.0001461241,0.0001421915,0.00002465948,0.0001115359,0.00002513075,0.00004534053,0.00006924973,0.000007261132],"category_scores_gemma":[0.00001985438,0.00009347254,0.00004748098,0.00008771751,0.00003942255,0.00001824648,0.00001603916,0.00009485013,4.902163e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003281505,"about_ca_system_score_gemma":0.00001513908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002904052,"about_ca_topic_score_gemma":0.00001061088,"domain_scores_codex":[0.9992195,0.0001455647,0.0001247454,0.0002831666,0.0001197298,0.0001072445],"domain_scores_gemma":[0.9997144,0.0000206638,0.00005162611,0.0001026611,0.0000448529,0.00006575033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001468535,0.00003519813,0.00009418387,0.00006909927,0.00002625417,3.395668e-7,0.0004664975,0.00003872642,0.9948844,0.0004663137,0.00004163072,0.002408784],"study_design_scores_gemma":[0.001145448,0.0004131248,0.002301505,0.0001109968,0.00005296135,0.000002908671,0.0001330741,0.0000401283,0.9945527,0.00008707845,0.001038477,0.0001216394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884987,0.0003977052,0.01004165,0.0004172943,0.00006373016,0.0004770328,0.00002301819,0.000009763265,0.0000710767],"genre_scores_gemma":[0.9988405,0.00004814452,0.00009943397,0.0007233522,0.0001718084,0.00004383391,0.00003496803,0.00001768323,0.00002028945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01034175,"threshold_uncertainty_score":0.3811699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004836187711905856,"score_gpt":0.2020924049710466,"score_spread":0.1972562172591407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}