{"id":"W3011995612","doi":"10.1016/j.jid.2019.10.026","title":"Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature","year":2020,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Agence Nationale de la Recherche; E-Rare; European Commission; Rare Disease Foundation","keywords":"Biology; Immunology; Kallikrein; Hair follicle; Stratum granulosum; Pathology; Cell biology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002184988,0.0002317178,0.0003916704,0.00007815024,0.000143745,0.00003051122,0.0001812615,0.000339357,0.00001193395],"category_scores_gemma":[0.0006496024,0.0001775848,0.00007769611,0.000154739,0.0006870576,0.00002452412,0.00006770765,0.0004471002,0.000001410812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001209446,"about_ca_system_score_gemma":0.0001703517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000304172,"about_ca_topic_score_gemma":0.00005335681,"domain_scores_codex":[0.9982884,0.0005330468,0.0004072586,0.0002937809,0.0001757917,0.000301724],"domain_scores_gemma":[0.9987684,0.0001267493,0.0003503952,0.00009378149,0.0003362116,0.0003244206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000487943,0.00005614292,0.07539133,0.00005981197,0.0005448639,0.0001840786,0.0004369167,0.00001635608,0.9210355,0.0001931802,0.001470555,0.0001233754],"study_design_scores_gemma":[0.002782842,0.0009231183,0.1118082,0.00005769438,0.0001648318,0.00192612,0.0001776506,0.000318917,0.8806228,0.0003650773,0.0005613739,0.0002913148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910458,0.002483062,0.002150559,0.004055808,0.000039003,0.0001636052,0.00002819784,0.000007001338,0.00002691011],"genre_scores_gemma":[0.9975225,0.0002194422,0.0006901821,0.001282522,0.00007849978,0.000006579205,0.0001374648,0.00002160585,0.00004121029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04041262,"threshold_uncertainty_score":0.7241698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01339027846783935,"score_gpt":0.2349225788766011,"score_spread":0.2215323004087617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}