{"id":"W3011995612","doi":"10.1016/j.jid.2019.10.026","title":"Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature","year":2020,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Agence Nationale de la Recherche; E-Rare; European Commission; Rare Disease Foundation","keywords":"Biology; Immunology; Kallikrein; Hair follicle; Stratum granulosum; Pathology; Cell biology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001745056,0.0009002652,0.0003387034,0.001062959,0.0002593033,0.0004325012,0.0003315624,0.000715603,0.004859269],"category_scores_gemma":[0.0001675802,0.0003757089,0.0004116693,0.0002998281,0.000682075,0.0002737728,0.0003857467,0.001238594,0.001005131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003231474,"about_ca_system_score_gemma":0.0002690833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006412342,"about_ca_topic_score_gemma":0.001177027,"domain_scores_codex":[0.9996321,0.00003462047,0.0000377185,0.00009827854,0.0001321815,0.00006498069],"domain_scores_gemma":[0.9992834,0.0000644444,0.0003398397,0.0000504305,0.00003618046,0.0002257051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001039014,0.00002012012,0.0001587627,0.00000976259,0.000005157108,0.0001714826,0.000009716714,0.00003078579,0.9990784,0.00008035815,0.00003004466,0.0003015747],"study_design_scores_gemma":[0.00008133605,0.000264177,0.01667692,0.00000964408,0.00005633801,0.003374673,0.00008416102,0.0008355271,0.9763,0.0002972027,0.002002317,0.00001762087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912447,0.0004048516,0.004552977,0.0001561569,0.00008129064,0.00003530678,0.00124471,0.0004191056,0.001860856],"genre_scores_gemma":[0.9828262,0.0003386398,0.00366205,0.00007488028,0.00002162118,0.00003773308,0.001128454,0.000170776,0.01173963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004859269,"threshold_uncertainty_score":0.01625586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01339027846783935,"score_gpt":0.2349225788766011,"score_spread":0.2215323004087617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}