{"id":"W3012042364","doi":"10.1038/s41380-020-0689-5","title":"Association of polygenic score for major depression with response to lithium in patients with bipolar disorder","year":2020,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; University of British Columbia; McGill University; Douglas Mental Health University Institute; McGill University Health Centre; University of Toronto; Dalhousie University; Montreal Neurological Institute and Hospital","funders":"National Institute on Drug Abuse; National Institute of Mental Health; Instituto de Salud Carlos III; Tartu Ülikool; Medical Research Council; Canadian Institutes of Health Research; McDonnell Center for Systems Neuroscience; National Institutes of Health; Deutsches Zentrum für Herz-Kreislaufforschung; Universitair Medisch Centrum Groningen; Rheinische Friedrich-Wilhelms-Universität Bonn; National Health and Medical Research Council; Region Hovedstaden; Universidad de Granada; Rigshospitalet; Centro de Investigación Biomédica en Red de Salud Mental; Queensland Brain Institute; University of Queensland; Karolinska Institutet; Generalitat de Catalunya; U.S. Department of Veterans Affairs; Grantová Agentura České Republiky; Bundesministerium für Bildung und Forschung; Ministerstvo Školství, Mládeže a Tělovýchovy; Westfälische Wilhelms-Universität Münster; Brigham and Women's Hospital; Queensland University of Technology; University of Adelaide; Institut National de la Santé et de la Recherche Médicale; Lundbeckfonden; Kaiser Permanente; Cardiff University; Vrije Universiteit Amsterdam; University of Oxford; Rijksuniversiteit Groningen; Fondation FondaMental; Deutsche Forschungsgemeinschaft; H. Lundbeck A/S; Centres de Recerca de Catalunya; Broad Institute; University of New South Wales; Stockholms Läns Landsting; Aarhus Universitet; F. Hoffmann-La Roche; Agence Nationale de la Recherche; University of Southern California; Wellcome Trust; Massachusetts General Hospital; Vetenskapsrådet; Virginia Commonwealth University","keywords":"Bipolar disorder; Genome-wide association study; Lithium (medication); Internal medicine; Depression (economics); Medicine; Quartile; Logistic regression; Genetic association; Psychiatry; Oncology; Psychology; Single-nucleotide polymorphism; Genetics; Genotype; Biology; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009750316,0.0001571431,0.0002472459,0.0001039187,0.00003301291,0.000007214215,0.00006410317,0.00007616113,0.00001213555],"category_scores_gemma":[0.00005780561,0.0001142166,0.00006995229,0.0003719917,0.0000115745,0.00003511867,0.00002129977,0.0001093718,0.00000507634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005711908,"about_ca_system_score_gemma":0.0001422488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004009104,"about_ca_topic_score_gemma":0.0002269138,"domain_scores_codex":[0.998907,0.00006528425,0.0001985632,0.0002957563,0.0003210675,0.0002123801],"domain_scores_gemma":[0.9994109,0.00002151975,0.00009987269,0.0002263935,0.0000998898,0.0001414445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01309901,0.0006519606,0.9837771,0.0001066165,0.0001898342,0.000001780945,0.0002373135,0.00002075537,0.001070483,0.00001308602,0.0001561291,0.0006759476],"study_design_scores_gemma":[0.01022108,0.00315362,0.9831666,0.0001532815,0.0002402497,9.459107e-7,0.00005333892,0.00001547825,0.001148795,0.00001854457,0.001691458,0.0001366575],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862945,0.002337488,0.002997461,0.006943886,0.00005157978,0.001267928,0.00004544243,0.00002467259,0.00003701371],"genre_scores_gemma":[0.9927462,0.000002614755,0.00613201,0.0008519964,0.00001810486,0.00007611969,0.00006651802,0.00004347261,0.00006294714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006451688,"threshold_uncertainty_score":0.4657616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004123162254669232,"score_gpt":0.2216934654059933,"score_spread":0.2175703031513241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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