{"id":"W3012042364","doi":"10.1038/s41380-020-0689-5","title":"Association of polygenic score for major depression with response to lithium in patients with bipolar disorder","year":2020,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; University of British Columbia; McGill University; Douglas Mental Health University Institute; McGill University Health Centre; University of Toronto; Dalhousie University; Montreal Neurological Institute and Hospital","funders":"National Institute on Drug Abuse; National Institute of Mental Health; Instituto de Salud Carlos III; Tartu Ülikool; Medical Research Council; Canadian Institutes of Health Research; McDonnell Center for Systems Neuroscience; National Institutes of Health; Deutsches Zentrum für Herz-Kreislaufforschung; Universitair Medisch Centrum Groningen; Rheinische Friedrich-Wilhelms-Universität Bonn; National Health and Medical Research Council; Region Hovedstaden; Universidad de Granada; Rigshospitalet; Centro de Investigación Biomédica en Red de Salud Mental; Queensland Brain Institute; University of Queensland; Karolinska Institutet; Generalitat de Catalunya; U.S. Department of Veterans Affairs; Grantová Agentura České Republiky; Bundesministerium für Bildung und Forschung; Ministerstvo Školství, Mládeže a Tělovýchovy; Westfälische Wilhelms-Universität Münster; Brigham and Women's Hospital; Queensland University of Technology; University of Adelaide; Institut National de la Santé et de la Recherche Médicale; Lundbeckfonden; Kaiser Permanente; Cardiff University; Vrije Universiteit Amsterdam; University of Oxford; Rijksuniversiteit Groningen; Fondation FondaMental; Deutsche Forschungsgemeinschaft; H. Lundbeck A/S; Centres de Recerca de Catalunya; Broad Institute; University of New South Wales; Stockholms Läns Landsting; Aarhus Universitet; F. Hoffmann-La Roche; Agence Nationale de la Recherche; University of Southern California; Wellcome Trust; Massachusetts General Hospital; Vetenskapsrådet; Virginia Commonwealth University","keywords":"Bipolar disorder; Genome-wide association study; Lithium (medication); Internal medicine; Depression (economics); Medicine; Quartile; Logistic regression; Genetic association; Psychiatry; Oncology; Psychology; Single-nucleotide polymorphism; Genetics; Genotype; Biology; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004492005,0.0003683796,0.0003872455,0.0006175785,0.0004829259,0.0005293836,0.0003006877,0.0006011151,0.002024459],"category_scores_gemma":[0.002175663,0.0001965151,0.0007110691,0.0007779074,0.0003023755,0.000298984,0.0003253831,0.0006972515,0.0001666854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002738796,"about_ca_system_score_gemma":0.000271158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004876498,"about_ca_topic_score_gemma":0.00658936,"domain_scores_codex":[0.9995247,0.0002176915,0.00005373488,0.0000840359,0.00005517372,0.0000646507],"domain_scores_gemma":[0.9982602,0.000523686,0.0006818851,0.0001566253,0.0001166372,0.0002609361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004811545,0.00005092238,0.9976522,0.000004377378,0.0001897301,0.0001038409,0.00002791871,0.00006550428,0.0005760349,0.00001672944,0.00005196712,0.0007795498],"study_design_scores_gemma":[0.000007753004,0.0001191,0.9991985,0.000001748889,0.00004463801,0.0001736013,0.0000384988,0.0003161491,0.00004263477,0.00002338279,0.00003096866,0.000003012389],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991692,0.0001351149,0.00007691011,0.0000690589,0.000009169244,0.000003173385,0.0001348803,0.000005213414,0.0003972311],"genre_scores_gemma":[0.9997059,0.00002107646,0.00004225481,0.00001973746,0.000006730278,0.000001763561,0.0001073489,0.000001325698,0.0000939744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004876498,"threshold_uncertainty_score":0.009696245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004123162254669232,"score_gpt":0.2216934654059933,"score_spread":0.2175703031513241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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