{"id":"W3012050575","doi":"10.1016/s0140-6736(20)30263-4","title":"Guselkumab in biologic-naive patients with active psoriatic arthritis (DISCOVER-2): a double-blind, randomised, placebo-controlled phase 3 trial","year":2020,"lang":"en","type":"article","venue":"The Lancet","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":344,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"Janssen Biotech; Janssen Research and Development; Celgene; Pfizer; School of Public Health, University of California Berkeley; North Carolina GlaxoSmithKline Foundation; Amgen; Boehringer Ingelheim; Gilead Sciences; Eli Lilly and Company; Bristol-Myers Squibb; AbbVie; Abbott Laboratories","keywords":"Medicine; Psoriatic arthritis; Placebo; Internal medicine; Clinical endpoint; Rheumatology; Arthritis; Placebo-controlled study; Clinical trial; Gastroenterology; Double blind; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002194596,0.002215432,0.004534622,0.0005472901,0.0006227285,0.001415672,0.001198919,0.003073164,0.008330151],"category_scores_gemma":[0.00181774,0.001021706,0.003160748,0.0006020301,0.00166478,0.001610784,0.0005303985,0.004217949,0.001622651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007579391,"about_ca_system_score_gemma":0.001148728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001361126,"about_ca_topic_score_gemma":0.003092206,"domain_scores_codex":[0.9992436,0.0003579773,0.0000420332,0.0001293591,0.00007097986,0.0001560432],"domain_scores_gemma":[0.99915,0.0002698173,0.0001842155,0.00007333216,0.00004955239,0.0002729825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9859633,0.002300351,0.0002552593,0.0008276916,0.000812124,0.00003765808,0.00004640335,0.0001219348,0.001636076,0.00009142806,0.0007563727,0.007151348],"study_design_scores_gemma":[0.9855261,0.01320138,0.0005322543,0.00002042929,0.0002223509,0.00001847037,0.00001180832,0.00006564272,0.00008154954,0.00005976935,0.0002525397,0.000007571],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9652422,0.01980752,0.001165511,0.001739332,0.001648145,0.004110569,0.002312173,0.0003120606,0.003662627],"genre_scores_gemma":[0.9670405,0.01103642,0.002213163,0.003112582,0.001151561,0.005629752,0.002315624,0.00007951562,0.007420894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008330151,"threshold_uncertainty_score":0.02786708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04151728404340694,"score_gpt":0.3027723905540369,"score_spread":0.2612551065106299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}