{"id":"W3012050575","doi":"10.1016/s0140-6736(20)30263-4","title":"Guselkumab in biologic-naive patients with active psoriatic arthritis (DISCOVER-2): a double-blind, randomised, placebo-controlled phase 3 trial","year":2020,"lang":"en","type":"article","venue":"The Lancet","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":344,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"Janssen Biotech; Janssen Research and Development; Celgene; Pfizer; School of Public Health, University of California Berkeley; North Carolina GlaxoSmithKline Foundation; Amgen; Boehringer Ingelheim; Gilead Sciences; Eli Lilly and Company; Bristol-Myers Squibb; AbbVie; Abbott Laboratories","keywords":"Medicine; Psoriatic arthritis; Placebo; Internal medicine; Clinical endpoint; Rheumatology; Arthritis; Placebo-controlled study; Clinical trial; Gastroenterology; Double blind; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001829618,0.0002691144,0.001443549,0.00004826739,0.0001233345,0.00003217472,0.0001440919,0.00007303008,0.0001198682],"category_scores_gemma":[0.0002585,0.0001415455,0.0001549494,0.0002518073,0.0001013761,0.00008515101,0.00005389548,0.000261562,0.00005696607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000749094,"about_ca_system_score_gemma":0.00008110893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007266006,"about_ca_topic_score_gemma":0.0001044982,"domain_scores_codex":[0.9984281,0.0001493645,0.0003807688,0.0003523793,0.0002805841,0.0004088065],"domain_scores_gemma":[0.999051,0.0002661222,0.0001969168,0.000303296,0.00007078995,0.0001118347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9866138,0.0008488325,0.001554532,0.00001438869,0.0007062175,0.0001059343,0.001211321,0.000006140215,0.00001152966,0.0000388253,0.0009490449,0.007939398],"study_design_scores_gemma":[0.9910666,0.005509863,0.001405468,0.00012656,0.0002853705,0.000004139329,0.0003025819,0.00002616263,0.0001229827,0.00005080984,0.0009390418,0.0001603623],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855915,0.0007733982,0.00001024771,0.003929892,0.0002486951,0.007433873,0.000130722,0.00005651033,0.001825191],"genre_scores_gemma":[0.9959942,0.0004865456,0.00005146256,0.001089374,0.001087117,0.001098422,0.0001187028,0.00002309761,0.00005109942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01040271,"threshold_uncertainty_score":0.577206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04151728404340694,"score_gpt":0.3027723905540369,"score_spread":0.2612551065106299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}