{"id":"W3012051999","doi":"10.1161/atvb.34.suppl_1.437","title":"Abstract 437: Lipoprotein(a) Internalization in HepG2 Cells is Regulated by Proprotein Convertase Subtilisin Kexin Type 9 Through the Low-Density Lipoprotein Receptor","year":2014,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; University of Windsor","funders":"","keywords":"Internalization; PCSK9; Kexin; Proprotein convertase; LDL receptor; Lipoprotein; Apolipoprotein B; Lipoprotein(a); Endocytosis; Subtilisin; Familial hypercholesterolemia; Receptor; Lysine; Low-density lipoprotein; Chemistry; Endocrinology; Biochemistry; Internal medicine; Cholesterol; Biology; Medicine; Amino acid; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001179313,0.0003602025,0.0003224602,0.0001214954,0.0003142531,0.0003596444,0.0001510751,0.0002331412,0.003487843],"category_scores_gemma":[0.00007319123,0.000139032,0.0004204589,0.0001976445,0.0001686428,0.0001715854,0.000180107,0.0004509606,0.002834745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004013574,"about_ca_system_score_gemma":0.0002799359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002681107,"about_ca_topic_score_gemma":0.001711934,"domain_scores_codex":[0.9998136,0.0000402443,0.00002185229,0.00002743994,0.00005359369,0.00004329661],"domain_scores_gemma":[0.9999152,0.00001551024,0.00001275915,0.00001811416,0.00002212137,0.00001619221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005663237,0.00008646202,0.0003503927,0.00006201295,0.00001035883,0.0001632637,0.00002683211,0.00004603592,0.9972603,0.0001090415,0.0002654548,0.001053417],"study_design_scores_gemma":[0.00008920443,0.0004820951,0.01129339,0.000008924251,0.0000244054,0.0005158328,0.0000635411,0.001748239,0.9812369,0.00006581689,0.004461377,0.0000102325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843336,0.002201833,0.003049518,0.000344264,0.0001490816,0.00007012208,0.00171116,0.0002117172,0.007928766],"genre_scores_gemma":[0.9786284,0.001191769,0.002581421,0.0001576921,0.00003410086,0.00008668347,0.003547857,0.00006581901,0.0137062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003487843,"threshold_uncertainty_score":0.01166803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01911220921216034,"score_gpt":0.2627362504811805,"score_spread":0.2436240412690202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}