{"id":"W3012092751","doi":"10.1172/jci127750","title":"Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Kidney Stones and Urolithiasis Treatments","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Common Fund; National Institute on Drug Abuse; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Human Genome Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; University of Tokyo; Royan Institute; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health; University of Alberta","keywords":"Hypercalciuria; Reabsorption; Endocrinology; Claudin; Nephrocalcinosis; Internal medicine; Paracellular transport; Kidney stones; Kidney; Kidney disease; Calcium; Medicine; Biology; Tight junction; Cell biology; Permeability (electromagnetism)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004613006,0.001109627,0.0005869002,0.002499815,0.0005858581,0.0006849889,0.0004671552,0.001429241,0.004973609],"category_scores_gemma":[0.0006069017,0.0006002082,0.0005115648,0.0008373249,0.000850554,0.0003592688,0.0007813657,0.001147981,0.0005458765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003531794,"about_ca_system_score_gemma":0.0003800847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008441198,"about_ca_topic_score_gemma":0.0008690924,"domain_scores_codex":[0.9993743,0.0001758205,0.0000714106,0.0001568752,0.0001467751,0.00007491151],"domain_scores_gemma":[0.9991818,0.0001839223,0.0003472809,0.00005419178,0.00003311919,0.0001995884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001832495,0.0004391777,0.007972839,0.0001624758,0.0001457852,0.005699429,0.0001932886,0.000298841,0.9774665,0.001114508,0.0005861582,0.004088522],"study_design_scores_gemma":[0.001626252,0.003367651,0.2658448,0.0003689203,0.001156503,0.1263921,0.0007054609,0.01017244,0.5584737,0.004358827,0.02735181,0.000181571],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898746,0.002631622,0.004017774,0.0005609599,0.00006246371,0.00005149343,0.000725133,0.0004154143,0.001660588],"genre_scores_gemma":[0.9921678,0.001400668,0.002867292,0.0001930462,0.00004480981,0.00005866559,0.0008002978,0.0001342314,0.002333198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004973609,"threshold_uncertainty_score":0.0166384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08169439349268456,"score_gpt":0.3774472819995895,"score_spread":0.295752888506905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}