{"id":"W3012106145","doi":"10.1158/1535-7163.mct-19-1117","title":"Elucidation of Pelareorep Pharmacodynamics in A Phase I Trial in Patients with <i>KRAS</i> -Mutated Colorectal Cancer","year":2020,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"ATCO (Canada)","funders":"National Cancer Institute; National Institute on Aging; American Society of Clinical Oncology","keywords":"FOLFIRI; Irinotecan; KRAS; Bevacizumab; Colorectal cancer; Medicine; Oxaliplatin; Cancer research; Cytotoxic T cell; Pharmacodynamics; Internal medicine; Pharmacology; Immunology; Oncology; Cancer; Biology; Pharmacokinetics; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005204479,0.000211298,0.0004695671,0.0000920641,0.00002309731,0.000007966522,0.00007038681,0.00006695784,0.00006647158],"category_scores_gemma":[0.000008386819,0.0001712525,0.00006924356,0.0006168772,0.00007206242,0.00005181464,0.00002732231,0.0001904866,6.512587e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003491812,"about_ca_system_score_gemma":0.000255065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003993921,"about_ca_topic_score_gemma":0.0004843631,"domain_scores_codex":[0.998705,0.00005371628,0.0003593625,0.0003029959,0.0003389199,0.0002400146],"domain_scores_gemma":[0.9995107,0.00001681762,0.0001474832,0.000097878,0.0001526527,0.00007443852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3979464,0.003873125,0.4669046,0.000237158,0.001576937,0.0001907685,0.005947162,0.001680631,0.05287731,0.00002412272,0.00004013642,0.06870167],"study_design_scores_gemma":[0.6734761,0.01753551,0.1729972,0.0004661584,0.001596686,0.000002091517,0.0004811263,0.01161813,0.1191632,0.00003281859,0.001804189,0.0008267863],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954622,0.001573723,0.0001050487,0.0009944576,0.0001120777,0.001440458,0.0001125071,0.00002231929,0.000177259],"genre_scores_gemma":[0.9976532,0.0005116613,0.00007004211,0.00133249,0.0000374656,0.0002767645,0.00007756455,0.00003505152,0.000005742743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2939073,"threshold_uncertainty_score":0.6983473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02100542955804359,"score_gpt":0.3223750773659806,"score_spread":0.301369647807937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}