{"id":"W3012116707","doi":"10.1007/s00294-020-01062-2","title":"N-degron-mediated degradation and regulation of mitochondrial PINK1 kinase","year":2020,"lang":"en","type":"review","venue":"Current Genetics","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"PINK1; Parkin; Mitophagy; Biology; Mitochondrion; Cell biology; Ubiquitin ligase; Degron; Autophagy; Ubiquitin; Genetics; Parkinson's disease; Gene; Medicine; Apoptosis; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004736472,0.0009331008,0.001179244,0.001102439,0.00017291,0.0008988107,0.0007742963,0.0008115724,0.00203353],"category_scores_gemma":[0.000336369,0.0002107265,0.0003397093,0.001062148,0.0004563953,0.001023634,0.0007185404,0.001484771,0.00188015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007750446,"about_ca_system_score_gemma":0.0008045484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005459654,"about_ca_topic_score_gemma":0.001281053,"domain_scores_codex":[0.9998676,0.00001931338,0.00001814476,0.00002491579,0.00005248589,0.00001762044],"domain_scores_gemma":[0.9998808,0.00003360942,0.00002868859,0.000005103996,0.00003194543,0.00001986444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002170053,0.00006871844,0.0001498419,0.01138178,0.0001053135,0.0003140643,0.00003598479,0.0004424081,0.009701118,0.005654005,0.04246875,0.9294611],"study_design_scores_gemma":[0.00004853023,0.0000902957,0.0008691176,0.001391315,0.00009661196,0.001110761,0.00003117345,0.0001743126,0.002513641,0.002965916,0.9906855,0.00002286905],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001906714,0.9978655,0.0002385796,0.000310567,0.0002698461,0.000004215075,0.00002269013,0.00001356906,0.001084414],"genre_scores_gemma":[0.001249824,0.9970291,0.0002288281,0.0002456862,0.000217637,0.000007611746,0.00006487061,0.000002370753,0.000954108],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00203353,"threshold_uncertainty_score":0.006802857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06342400532519474,"score_gpt":0.3593242464296933,"score_spread":0.2959002411044985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}