{"id":"W3012169730","doi":"10.1016/j.jaut.2020.102439","title":"Gene expression profiling of epithelium-associated FcRL4+ B cells in primary Sjögren's syndrome reveals a pathogenic signature","year":2020,"lang":"en","type":"article","venue":"Journal of Autoimmunity","topic":"Salivary Gland Disorders and Functions","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Arthritis Society; National Institutes of Health; ReumaNederland; Dutch Arthritis Society","keywords":"CD19; Memory B cell; B cell; Biology; Flow cytometry; Cancer research; Molecular biology; Chemistry; Immunology; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006642047,0.0001481081,0.0006689052,0.0001757428,0.00006282401,0.000008592697,0.0001603656,0.0001889658,0.0001168216],"category_scores_gemma":[0.0004055021,0.0001131539,0.0002444759,0.0004610631,0.00004071254,0.0001335355,0.00006521004,0.0008968529,0.000004504082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008429178,"about_ca_system_score_gemma":0.0002802371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001668922,"about_ca_topic_score_gemma":5.366308e-7,"domain_scores_codex":[0.9983316,0.0002282023,0.0007759045,0.000114795,0.000357714,0.0001917637],"domain_scores_gemma":[0.9986392,0.0001375891,0.0006428955,0.0001941455,0.0002432052,0.0001430098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006977291,0.0006483468,0.03920616,0.0001759558,0.00009864034,0.0003192691,0.0008610058,0.000156441,0.9567923,0.000002225729,0.0005936835,0.0004482729],"study_design_scores_gemma":[0.007574078,0.002803316,0.8920087,0.001429878,0.0003375368,0.0004898869,0.001012465,0.0002678783,0.09328038,0.0003081394,0.0002081699,0.0002796019],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958347,0.002632395,0.000142627,0.0006333088,0.0001756238,0.0002291855,0.0000386658,0.00001803905,0.0002954231],"genre_scores_gemma":[0.9965453,0.0003268659,0.002435149,0.0005243797,0.00005438058,0.000002167179,0.00003112245,0.0000197336,0.00006092804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8635119,"threshold_uncertainty_score":0.4614284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01789189552355149,"score_gpt":0.235621433181583,"score_spread":0.2177295376580315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}