{"id":"W3012203653","doi":"10.1016/j.yexcr.2020.111957","title":"Extracellular microparticles exacerbate oxidative damage to retinal pigment epithelial cells","year":2020,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Oxidative stress; Cell biology; Biology; Retinal pigment epithelium; Extracellular; Retina; Intracellular; Retinal; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006166549,0.0002755898,0.0001910133,0.00007080502,0.0002531708,0.000114836,0.0006859698,0.0001244391,0.0005687013],"category_scores_gemma":[0.00007937789,0.0002886228,0.0001318422,0.000292441,0.0002904082,0.00001140883,0.000962213,0.0003225311,0.001236424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008369506,"about_ca_system_score_gemma":0.0001253941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002401068,"about_ca_topic_score_gemma":0.000001847866,"domain_scores_codex":[0.9967328,0.000493606,0.0003308857,0.0009191397,0.0007121532,0.0008114642],"domain_scores_gemma":[0.9983246,0.00003501449,0.00005586088,0.0005892679,0.0001364019,0.0008588974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007904135,0.0004546095,0.00009286319,0.00002983331,0.0000213627,0.0001143196,0.00120298,0.00007551587,0.9856115,0.00007961309,0.01130069,0.0002262865],"study_design_scores_gemma":[0.0007742287,0.001347447,0.00005199507,0.000009695284,0.000006163399,0.000002194682,0.00214398,0.0001424868,0.9440686,0.00001362751,0.05112756,0.0003120577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906253,0.004550038,0.0007599245,0.0006149606,0.00009462578,0.0007783308,0.00005717484,0.00003034735,0.002489358],"genre_scores_gemma":[0.9927797,0.00005412944,0.002915079,0.0003379931,0.000445776,0.0001103444,0.0000696643,0.00007574658,0.003211598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04154294,"threshold_uncertainty_score":0.9999566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04745384726079985,"score_gpt":0.3429345293113513,"score_spread":0.2954806820505514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}