{"id":"W3012211882","doi":"10.1534/genetics.120.303060","title":"Topoisomerases Modulate the Timing of Meiotic DNA Breakage and Chromosome Morphogenesis in <i>Saccharomyces cerevisiae</i>","year":2020,"lang":"en","type":"article","venue":"Genetics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institutes of Health; York University","keywords":"Synapsis; Biology; Meiosis; Genetics; Prophase; Chromosome segregation; Synaptonemal complex; Saccharomyces cerevisiae; Chromosome; Chromosomal crossover; Homologous recombination; Genetic recombination; DNA; Cell biology; Gene; Recombination","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005862659,0.0003050786,0.0001631016,0.0001601133,0.0001189146,0.0004930813,0.0001563202,0.0001582561,0.0009782126],"category_scores_gemma":[0.00008569367,0.0001761968,0.0001501807,0.0001164741,0.0001124604,0.0001362434,0.0001984389,0.0002724249,0.0003344912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003556646,"about_ca_system_score_gemma":0.0001230508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001958388,"about_ca_topic_score_gemma":0.002662324,"domain_scores_codex":[0.9999403,0.000005354665,0.000005198613,0.00001784732,0.00001464912,0.00001666185],"domain_scores_gemma":[0.9998832,0.00001091875,0.00003697616,0.000009031755,0.00001703867,0.0000428469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007857651,0.000006953129,0.0005975749,0.00001444847,0.00000344739,0.00001947192,0.000007566851,0.00003478163,0.998686,0.00001898265,0.00003006195,0.0005021722],"study_design_scores_gemma":[0.00001180927,0.0001254485,0.04141236,0.000005487687,0.00001728538,0.00009542029,0.0000783092,0.001052668,0.9555554,0.0000331719,0.001604152,0.000008422991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966607,0.001088671,0.0007152391,0.00003113703,0.00001774321,0.000009119633,0.0007060129,0.0001082452,0.0006632378],"genre_scores_gemma":[0.9977303,0.0003122232,0.000359672,0.00002010808,0.000003826864,0.000007360783,0.000491396,0.00002978602,0.001045383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001958388,"threshold_uncertainty_score":0.003893971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02210100909186472,"score_gpt":0.2382370975488694,"score_spread":0.2161360884570047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}