{"id":"W3012211882","doi":"10.1534/genetics.120.303060","title":"Topoisomerases Modulate the Timing of Meiotic DNA Breakage and Chromosome Morphogenesis in <i>Saccharomyces cerevisiae</i>","year":2020,"lang":"en","type":"article","venue":"Genetics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institutes of Health; York University","keywords":"Synapsis; Biology; Meiosis; Genetics; Prophase; Chromosome segregation; Synaptonemal complex; Saccharomyces cerevisiae; Chromosome; Chromosomal crossover; Homologous recombination; Genetic recombination; DNA; Cell biology; Gene; Recombination","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007479407,0.0001318042,0.0001645046,0.00002034497,0.00003808177,0.00001642902,0.000170938,0.00007193336,0.00002266889],"category_scores_gemma":[0.00001156202,0.0001081432,0.00005274979,0.0001098787,0.00006238979,0.000001932611,0.0001268213,0.00005098995,0.000001586847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005254009,"about_ca_system_score_gemma":0.00003299255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001689397,"about_ca_topic_score_gemma":0.0000314171,"domain_scores_codex":[0.9992366,0.00003431331,0.000204821,0.0002505619,0.0001013529,0.0001723965],"domain_scores_gemma":[0.9995919,0.0000122556,0.00007386236,0.0002271509,0.00002912311,0.00006567607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002284585,0.00001544969,0.0006859886,0.00004212205,0.00003439851,0.000002365366,0.0001738472,0.0002496755,0.9926916,0.00004264415,0.00007652638,0.005962481],"study_design_scores_gemma":[0.0004059771,0.0002601711,0.001456309,0.00001719111,0.00004091492,0.00001117984,0.0001258207,0.0009315989,0.9898952,0.0001351882,0.006559982,0.0001605012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902548,0.008303632,0.0004090763,0.0007146446,0.00005321823,0.0001638447,0.00003255544,0.00000495055,0.00006323792],"genre_scores_gemma":[0.9943822,0.003968818,0.0005033664,0.0009493641,0.000127456,0.000008391117,0.00001381031,0.00002165523,0.00002491565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006483455,"threshold_uncertainty_score":0.4409951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02210100909186472,"score_gpt":0.2382370975488694,"score_spread":0.2161360884570047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}