{"id":"W3012251781","doi":"10.3390/cancers12030648","title":"Benefits of Combined All-Trans Retinoic Acid and Arsenic Trioxide Treatment of Acute Promyelocytic Leukemia Cells and Further Enhancement by Inhibition of Atypically Expressed Transglutaminase 2","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Nemzeti Kutatási, Fejlesztési és Innovaciós Alap; Natural Sciences and Engineering Research Council of Canada","keywords":"Arsenic trioxide; Acute promyelocytic leukemia; Retinoic acid; Tretinoin; Tumor necrosis factor alpha; Inflammation; Cancer research; Differentiation therapy; Medicine; Reactive oxygen species; Tissue transglutaminase; Chemistry; Monocyte; Pharmacology; Immunology; Apoptosis; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003303155,0.0005306957,0.0009306628,0.0002827694,0.0001530778,0.000434604,0.0002845757,0.0004044778,0.001420286],"category_scores_gemma":[0.0002155503,0.0001503035,0.0005615355,0.0001890713,0.0001966505,0.0002913029,0.0003231637,0.0007433288,0.000274887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001485286,"about_ca_system_score_gemma":0.0003055516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000239846,"about_ca_topic_score_gemma":0.0006292735,"domain_scores_codex":[0.9997764,0.00008299026,0.0000248011,0.00003236608,0.00004110899,0.00004230026],"domain_scores_gemma":[0.999826,0.00002531746,0.00004439806,0.00002578919,0.00001651407,0.00006183202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03324952,0.002478676,0.003222871,0.0005852957,0.000466072,0.0004481568,0.00006565468,0.0007504702,0.8711896,0.0003772835,0.0006316758,0.0865347],"study_design_scores_gemma":[0.01091448,0.1391677,0.06542762,0.0001717362,0.003592769,0.00471776,0.0003197833,0.003547449,0.7297807,0.0007568606,0.04153193,0.00007107518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812862,0.0149711,0.0009119977,0.0003600074,0.0001239041,0.00008120869,0.0001495603,0.0001047158,0.002011158],"genre_scores_gemma":[0.9946536,0.002843315,0.0008365703,0.0001603017,0.00008377139,0.00004587086,0.0002454957,0.000009910605,0.00112111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001420286,"threshold_uncertainty_score":0.004751325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009576702352917136,"score_gpt":0.2219296216448091,"score_spread":0.212352919291892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}