{"id":"W3012251781","doi":"10.3390/cancers12030648","title":"Benefits of Combined All-Trans Retinoic Acid and Arsenic Trioxide Treatment of Acute Promyelocytic Leukemia Cells and Further Enhancement by Inhibition of Atypically Expressed Transglutaminase 2","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Nemzeti Kutatási, Fejlesztési és Innovaciós Alap; Natural Sciences and Engineering Research Council of Canada","keywords":"Arsenic trioxide; Acute promyelocytic leukemia; Retinoic acid; Tretinoin; Tumor necrosis factor alpha; Inflammation; Cancer research; Differentiation therapy; Medicine; Reactive oxygen species; Tissue transglutaminase; Chemistry; Monocyte; Pharmacology; Immunology; Apoptosis; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004154267,0.000169103,0.0003020352,0.00001825635,0.00001654971,0.000004102992,0.00006675577,0.0001201506,0.00001337854],"category_scores_gemma":[0.000006756985,0.0001540494,0.00006921635,0.00006533876,0.0001999572,0.000005247082,0.00001663232,0.00003858661,1.507803e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008941528,"about_ca_system_score_gemma":0.0002570099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002176058,"about_ca_topic_score_gemma":0.000003875927,"domain_scores_codex":[0.999084,0.00003419781,0.0003178077,0.0003045085,0.000113436,0.0001460743],"domain_scores_gemma":[0.9995202,0.00001031491,0.0001681085,0.0001492982,0.0000614326,0.00009063198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009334963,0.00003381735,0.00006873978,0.000336674,0.0001866896,0.000001385896,0.0009509769,0.00009697868,0.9947518,0.000005858271,0.00008919617,0.002544423],"study_design_scores_gemma":[0.002748758,0.002598829,0.00006829809,0.00006494502,0.0002003468,0.000001508967,0.000142882,0.00008428585,0.9933916,0.000009867525,0.0005521211,0.0001365041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942767,0.004260773,0.0007756381,0.000103195,0.00002138589,0.0003344642,0.0001665417,0.000004451904,0.00005686279],"genre_scores_gemma":[0.9909675,0.008415404,0.0003320269,0.00005866918,0.0000205556,0.00003466503,0.00009937913,0.00001711876,0.00005472631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004154631,"threshold_uncertainty_score":0.6281952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009576702352917136,"score_gpt":0.2219296216448091,"score_spread":0.212352919291892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}