{"id":"W3012262711","doi":"10.1038/s41564-020-0687-z","title":"Structural coordination of polymerization and crosslinking by a SEDS–bPBP peptidoglycan synthase complex","year":2020,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":141,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; U.S. Department of Health and Human Services; Government of Canada; National Institutes of Health; Canadian Institutes of Health Research; Harvard Medical School; Howard Hughes Medical Institute","keywords":"Peptidoglycan; ATP synthase; Polymerization; Chemistry; Enzyme; Cell biology; Biochemistry; Biology; Organic chemistry; Polymer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000686417,0.0001292656,0.0002175938,0.00003909981,0.0001022377,0.00002536813,0.0001124013,0.0002958894,0.0002973378],"category_scores_gemma":[0.00008440994,0.0001108277,0.00002881076,0.0001395214,0.000182774,0.00009490554,0.00005411423,0.0002076578,0.000004671241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001584726,"about_ca_system_score_gemma":0.00002128189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002451606,"about_ca_topic_score_gemma":0.00001026712,"domain_scores_codex":[0.9992153,0.0000730659,0.0002080037,0.0002905557,0.00004801156,0.0001650788],"domain_scores_gemma":[0.9995695,0.00004394593,0.0001645193,0.00009007585,0.00008322374,0.0000487316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008246308,0.000003539261,0.0005787771,0.00003521701,0.000006815107,7.424026e-7,0.0002985759,0.000006922675,0.9949574,0.0006577149,0.002740619,0.0006311976],"study_design_scores_gemma":[0.0006074837,0.0001758703,0.001461963,0.00001133918,0.00002118984,0.00004594656,0.00007397961,0.0003245515,0.9926306,0.0001302688,0.004359226,0.000157595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961891,0.0007219974,0.0009248802,0.001249106,0.0003540363,0.0001272468,0.0002874196,0.00004980354,0.00009647403],"genre_scores_gemma":[0.9974305,0.000004434272,0.0008096354,0.001161917,0.0001359674,0.000001728072,0.0004239063,0.00001059586,0.00002130894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002326829,"threshold_uncertainty_score":0.4519421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00893969445260255,"score_gpt":0.2333411276452824,"score_spread":0.2244014331926799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}