{"id":"W3012265841","doi":"10.1056/nejmoa1912387","title":"Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol","year":2020,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":1564,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Esperion Therapeutics; HLS Therapeutics; Imperial College London; Daiichi Sankyo Europe; Silence Therapeutics; Sanofi; Kowa Company; Novo Nordisk; National Institute for Health and Care Research; Medicines Company; REGENXBIO; Regeneron Pharmaceuticals; Eli Lilly and Company; AstraZeneca; CSL Behring; Gilead Sciences; NIHR Imperial Biomedical Research Centre; Singulex; Amgen; Pfizer","keywords":"Ldl cholesterol; Phase (matter); Cholesterol; Internal medicine; Medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00319324,0.001476212,0.002293501,0.0004270971,0.0005002288,0.001032334,0.0009055043,0.001711267,0.005933929],"category_scores_gemma":[0.00292758,0.0006196098,0.001725807,0.0004429585,0.0006440179,0.0008684343,0.0005384594,0.003280781,0.0009068529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007663016,"about_ca_system_score_gemma":0.001472278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005138948,"about_ca_topic_score_gemma":0.001545968,"domain_scores_codex":[0.9987555,0.0007426289,0.00009353456,0.0001375174,0.0001019945,0.0001688393],"domain_scores_gemma":[0.9983636,0.0004595683,0.0003726673,0.0001584865,0.0001729148,0.0004728294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9340006,0.01199044,0.001199279,0.001136574,0.0009760048,0.0001197717,0.0001423236,0.0004981682,0.006041406,0.0002676782,0.002621775,0.04100593],"study_design_scores_gemma":[0.944697,0.05103499,0.001615079,0.00004549239,0.0002149057,0.00006447921,0.00002168402,0.0001673472,0.000363418,0.0001316895,0.001632112,0.00001180842],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9596516,0.01273594,0.00217273,0.002359001,0.0008301436,0.01346536,0.00242,0.0002485417,0.006116686],"genre_scores_gemma":[0.9422028,0.008087447,0.005429113,0.004813039,0.0008685434,0.028098,0.00413957,0.00006355593,0.006297882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005933929,"threshold_uncertainty_score":0.01985103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03953983517206699,"score_gpt":0.3263639915282541,"score_spread":0.2868241563561871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}