{"id":"W3012293314","doi":"10.2217/fon-2020-0044","title":"MIRROS: A Randomized, Placebo-Controlled, Phase III Trial of Cytarabine ± Idasanutlin in Relapsed or Refractory Acute Myeloid Leukemia","year":2020,"lang":"en","type":"article","venue":"Future Oncology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Medicine; Cytarabine; Myeloid leukemia; Refractory (planetary science); Internal medicine; Placebo; Oncology; Randomized controlled trial; Myeloid; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009617419,0.00149047,0.001469584,0.0003453459,0.0003560416,0.00079337,0.0008405037,0.0009919306,0.0113618],"category_scores_gemma":[0.001132271,0.0003865864,0.0008603024,0.0003162213,0.0008905072,0.0007563694,0.0003662106,0.00241661,0.001363563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005575138,"about_ca_system_score_gemma":0.001397046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006476213,"about_ca_topic_score_gemma":0.0026937,"domain_scores_codex":[0.999718,0.0001497219,0.00001419497,0.00004877015,0.00003163079,0.00003774913],"domain_scores_gemma":[0.9996445,0.00006361559,0.00009647247,0.00002593408,0.00002485534,0.0001444452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9496425,0.006523974,0.0003986801,0.001287827,0.0005726442,0.0000526955,0.00005924822,0.0004159806,0.005374798,0.0007006515,0.003711427,0.03125966],"study_design_scores_gemma":[0.9601614,0.03622997,0.0005606842,0.00005026519,0.0001398697,0.00003422558,0.00002005009,0.0002433295,0.0003780822,0.0002024939,0.00197206,0.000007576731],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9541463,0.008008415,0.001622454,0.001931558,0.001607566,0.01671763,0.004040163,0.0005471767,0.01137885],"genre_scores_gemma":[0.9388293,0.00873191,0.006341456,0.003093362,0.001081513,0.0178668,0.004810153,0.00009818102,0.01914723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0113618,"threshold_uncertainty_score":0.03800905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02589568544120383,"score_gpt":0.3477053238999175,"score_spread":0.3218096384587137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}