{"id":"W3012317413","doi":"10.1002/chem.201905826","title":"Through the Looking Glass: Chiral Recognition of Substrates and Products at the Active Sites of Racemases and Epimerases","year":2020,"lang":"en","type":"review","venue":"Chemistry - A European Journal","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Stereocenter; Stereochemistry; Enantiomer; Chemistry; Stereospecificity; Enzyme; Docking (animal); Enantioselective synthesis; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005394401,0.0009626311,0.001230225,0.001508914,0.0002735722,0.001197363,0.001216999,0.001294451,0.002951503],"category_scores_gemma":[0.0005249848,0.0004490206,0.0004545769,0.001549114,0.0008392371,0.002359574,0.0008615846,0.00257539,0.003609488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000827663,"about_ca_system_score_gemma":0.0005868527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007509778,"about_ca_topic_score_gemma":0.001242733,"domain_scores_codex":[0.9998024,0.00003469495,0.00001847579,0.00003974808,0.00007560373,0.00002913241],"domain_scores_gemma":[0.9998631,0.00005632587,0.00002090585,0.000006522332,0.00003237954,0.00002069842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001290313,0.00006202721,0.0001289424,0.01403696,0.00008016644,0.0003286256,0.0001140021,0.0009516355,0.007705698,0.02189769,0.04265025,0.9119151],"study_design_scores_gemma":[0.0000142919,0.00005482475,0.0002325083,0.000928345,0.00002784728,0.0006455304,0.00002496807,0.00008888511,0.00102851,0.003064833,0.9938745,0.00001494222],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001543637,0.9972653,0.0003909785,0.0002322821,0.0002538226,0.000004312561,0.00001426661,0.00001451443,0.001670156],"genre_scores_gemma":[0.001208211,0.9961193,0.0003591451,0.0002896251,0.0001721011,0.000007542395,0.00003743135,0.000004376091,0.001802253],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002951503,"threshold_uncertainty_score":0.009873748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02846136309546935,"score_gpt":0.2681825852957024,"score_spread":0.2397212222002331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}