{"id":"W3012345794","doi":"10.1038/s42003-020-0802-y","title":"Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error","year":2020,"lang":"en","type":"review","venue":"Communications Biology","topic":"Corneal surgery and disorders","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Medical Research Council; National Health and Medical Research Council; Sight Research UK; National Institutes of Health; Stichting Nederlands Oogheelkundig Onderzoek; Landelijke Stichting voor Blinden en Slechtzienden; Algemene Nederlandse Vereniging ter voorkoming van Blindheid; National Natural Science Foundation of China; Nelly Reef Fund; Medical Research Council; Oogfonds; ODAS Stichting; ZonMw; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ophthalmic Research Institute of Australia; Pfizer Australia; Stichting Dondersfonds; Erasmus Medisch Centrum; University of Bristol; National Institute for Health and Care Research; Stichting Steunfonds Uitzicht; European Commission; Pfizer; American Health Assistance Foundation","keywords":"Emmetropia; Genome-wide association study; Biology; Genetics; Quantitative trait locus; Population; Genetic association; Refractive error; Single-nucleotide polymorphism; Gene; Genotype; Medicine; Eye disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002235906,0.001196566,0.00408242,0.002189236,0.0002052122,0.001156901,0.0009688451,0.0008592301,0.002434724],"category_scores_gemma":[0.003303631,0.0003590678,0.004781978,0.00392255,0.0002562575,0.000443104,0.0007365341,0.0009320479,0.0003827514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004704904,"about_ca_system_score_gemma":0.001138775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00271251,"about_ca_topic_score_gemma":0.006184423,"domain_scores_codex":[0.9991211,0.0003020009,0.0001508082,0.0002072751,0.0001507829,0.00006796604],"domain_scores_gemma":[0.9981803,0.001284946,0.0002166009,0.00008768642,0.0001607187,0.00006973778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003964122,0.00009766559,0.05664822,0.1359726,0.2280307,0.001066086,0.0001820712,0.001453302,0.003410487,0.001387477,0.01442349,0.5533638],"study_design_scores_gemma":[0.0009943825,0.0009637524,0.2304627,0.02109054,0.6327662,0.003793179,0.0002863808,0.00119719,0.002109077,0.003908996,0.1022613,0.0001662562],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003273846,0.9954933,0.0003341285,0.0002589861,0.00008160839,0.00001076709,0.0002584088,0.00001765239,0.0002712948],"genre_scores_gemma":[0.06133651,0.9355742,0.001069104,0.0004480587,0.0001861662,0.00004750772,0.0009681843,0.0000193891,0.0003508759],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00408242,"threshold_uncertainty_score":0.01182473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1852022680783223,"score_gpt":0.4177057267268083,"score_spread":0.2325034586484861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}