{"id":"W3012345794","doi":"10.1038/s42003-020-0802-y","title":"Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error","year":2020,"lang":"en","type":"review","venue":"Communications Biology","topic":"Corneal surgery and disorders","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Medical Research Council; National Health and Medical Research Council; Sight Research UK; National Institutes of Health; Stichting Nederlands Oogheelkundig Onderzoek; Landelijke Stichting voor Blinden en Slechtzienden; Algemene Nederlandse Vereniging ter voorkoming van Blindheid; National Natural Science Foundation of China; Nelly Reef Fund; Medical Research Council; Oogfonds; ODAS Stichting; ZonMw; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ophthalmic Research Institute of Australia; Pfizer Australia; Stichting Dondersfonds; Erasmus Medisch Centrum; University of Bristol; National Institute for Health and Care Research; Stichting Steunfonds Uitzicht; European Commission; Pfizer; American Health Assistance Foundation","keywords":"Emmetropia; Genome-wide association study; Biology; Genetics; Quantitative trait locus; Population; Genetic association; Refractive error; Single-nucleotide polymorphism; Gene; Genotype; Medicine; Eye disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004525277,0.0002853875,0.003002882,0.0002351422,0.0002004845,0.00003349766,0.0004005345,0.0004863673,0.00007591743],"category_scores_gemma":[0.001745909,0.0002232343,0.0008107331,0.0009182927,0.0004329308,0.00006741221,0.0005505899,0.0005466838,0.000005227826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007996236,"about_ca_system_score_gemma":0.0001674308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002056562,"about_ca_topic_score_gemma":0.000820143,"domain_scores_codex":[0.9979928,0.0005040467,0.000789353,0.000405555,0.0001069135,0.0002013515],"domain_scores_gemma":[0.994827,0.002758427,0.001060194,0.001009568,0.0002497744,0.00009498449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00019525,0.0008008585,0.09726915,0.006346929,0.6176486,0.000006136292,0.005372785,0.000008483556,0.0001265072,0.00039086,0.0006538669,0.2711806],"study_design_scores_gemma":[0.0001792823,0.00005517496,0.04891898,0.00006583701,0.1899008,0.00000636466,0.0001524226,0.00002211767,2.983877e-7,0.00006703469,0.7604289,0.0002028465],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002529838,0.9939127,0.00005408021,0.001192574,0.0000291701,0.0005277114,0.001630086,0.00002264096,0.0001012151],"genre_scores_gemma":[0.01603436,0.9794062,0.0006606459,0.0002333819,0.00002015341,0.0001423421,0.003375539,0.00001687126,0.0001104668],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.759775,"threshold_uncertainty_score":0.9103229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1852022680783223,"score_gpt":0.4177057267268083,"score_spread":0.2325034586484861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}