{"id":"W3012355718","doi":"10.1093/neuonc/noaa059","title":"MGMT promoter methylation level in newly diagnosed low-grade glioma is a predictor of hypermutation at recurrence","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; University of California, San Francisco; National Institutes of Health; National Institute of General Medical Sciences; University of Oklahoma","keywords":"Somatic hypermutation; Methyltransferase; Biology; Temozolomide; Methylation; Cancer research; Glioma; O-6-methylguanine-DNA methyltransferase; DNA methylation; Bisulfite sequencing; Oncology; Medicine; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010422,0.0001750266,0.0004737573,0.0001700547,0.00003022985,0.000006184468,0.00008095909,0.0001736279,0.0001423765],"category_scores_gemma":[0.0005953247,0.0001538714,0.00009898838,0.0004653271,0.00006959725,0.00009020513,0.00006296964,0.0001770145,0.0000515769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002304266,"about_ca_system_score_gemma":0.0001675257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005912988,"about_ca_topic_score_gemma":0.00006909913,"domain_scores_codex":[0.9984546,0.0001731553,0.000463044,0.0004197789,0.0002555702,0.0002338618],"domain_scores_gemma":[0.9988636,0.0004510307,0.0002140563,0.0001928157,0.0001034816,0.0001749855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004814726,0.001230117,0.1161071,0.0001334207,0.00005244653,0.001014878,0.003754119,0.00003123582,0.8523317,0.0000397453,0.002404546,0.02241923],"study_design_scores_gemma":[0.01324689,0.004758665,0.3160374,0.0001187905,0.0002197361,0.0001129037,0.0001132507,0.003067602,0.6530672,0.0001252286,0.008943897,0.0001883944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98333,0.0002082558,0.0000444367,0.01489901,0.0002064216,0.0009537436,0.00005977489,0.00003803283,0.0002603685],"genre_scores_gemma":[0.9970962,0.00007770312,0.0005358784,0.001922819,0.0001113029,0.0001614254,0.00006718521,0.0000231346,0.000004337418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1999303,"threshold_uncertainty_score":0.6274694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0566727774134514,"score_gpt":0.3176718136678781,"score_spread":0.2609990362544267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}