{"id":"W3012355718","doi":"10.1093/neuonc/noaa059","title":"MGMT promoter methylation level in newly diagnosed low-grade glioma is a predictor of hypermutation at recurrence","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; University of California, San Francisco; National Institutes of Health; National Institute of General Medical Sciences; University of Oklahoma","keywords":"Somatic hypermutation; Methyltransferase; Biology; Temozolomide; Methylation; Cancer research; Glioma; O-6-methylguanine-DNA methyltransferase; DNA methylation; Bisulfite sequencing; Oncology; Medicine; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000292771,0.0001792962,0.0002667593,0.0004153374,0.0001287644,0.0002345557,0.0002026122,0.0002846422,0.001039924],"category_scores_gemma":[0.001821551,0.00009032293,0.0002843279,0.0003016971,0.0001520858,0.0001560154,0.0001811414,0.0003975538,0.0001837229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002854983,"about_ca_system_score_gemma":0.0002155859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003075823,"about_ca_topic_score_gemma":0.004922422,"domain_scores_codex":[0.9998777,0.00002186103,0.00001567528,0.00003007954,0.00003259491,0.00002210622],"domain_scores_gemma":[0.9988452,0.0002323975,0.0005203673,0.00005280406,0.000107724,0.0002414161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001745417,0.00001264664,0.9958662,0.000006285974,0.00002739454,0.00004217848,0.0000162736,0.0001018613,0.00141008,0.000004091602,0.00004715384,0.002291259],"study_design_scores_gemma":[0.000004202742,0.000107215,0.9982363,0.000002235442,0.00002874415,0.0003121671,0.0000295598,0.0005057756,0.0006709905,0.00001651271,0.00008449834,0.00000193386],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994124,0.0002078614,0.0001087565,0.00003145348,0.000002271689,0.000003366974,0.00008645423,0.0000078008,0.000139581],"genre_scores_gemma":[0.9996264,0.00006149522,0.00008363133,0.000008078957,0.00000313492,0.000002348475,0.0001492779,0.000001667842,0.00006387488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003075823,"threshold_uncertainty_score":0.006115794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0566727774134514,"score_gpt":0.3176718136678781,"score_spread":0.2609990362544267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}