{"id":"W3012374449","doi":"10.1101/2020.03.19.998740","title":"The pregnant myometrium is epigenetically activated at contractility-driving gene loci prior to the onset of labor in mice","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; SickKids Foundation; University of Toronto","funders":"Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research","keywords":"H3K4me3; Myometrium; Biology; Epigenetics; Chromatin immunoprecipitation; Chromatin; Gene; RNA polymerase II; Histone; Contractility; Gene expression; Internal medicine; Genetics; Promoter; Endocrinology; Pregnancy; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002255488,0.000355836,0.0003567318,0.0008595535,0.0002546269,0.0005221335,0.0002966127,0.0004538874,0.002869855],"category_scores_gemma":[0.000180368,0.0005991351,0.0005768572,0.000235313,0.0005583714,0.0002559093,0.00043461,0.001068596,0.0007336351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004008971,"about_ca_system_score_gemma":0.0002587092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008907044,"about_ca_topic_score_gemma":0.001643247,"domain_scores_codex":[0.9996529,0.00002991657,0.00002493473,0.000134213,0.00007483426,0.00008327398],"domain_scores_gemma":[0.9995989,0.00003625444,0.0001809848,0.00004569597,0.00002616966,0.0001119668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002874137,0.00002340581,0.001149304,0.00002746582,0.000009738419,0.00004478161,0.00003917161,0.00004900314,0.9968796,0.0001068378,0.00004975148,0.001333482],"study_design_scores_gemma":[0.00005903685,0.0006113193,0.07709102,0.00004440524,0.00008910226,0.0003817492,0.0002152682,0.001345934,0.9152707,0.0002607002,0.004606634,0.00002403774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862417,0.001481984,0.006647633,0.0002165232,0.00006389931,0.00003493082,0.003417273,0.0003564551,0.001539532],"genre_scores_gemma":[0.982869,0.0009712411,0.003809081,0.0002715934,0.0000211717,0.0001719207,0.002390726,0.0002743536,0.009220906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002869855,"threshold_uncertainty_score":0.00960058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01493787991477297,"score_gpt":0.2299619294749475,"score_spread":0.2150240495601746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}