{"id":"W3012375939","doi":"10.1101/2020.03.10.986380","title":"Lipid-associated PML domains regulate CCTα, Lipin1 and lipid homeostasis","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; University College London; Francis Crick Institute; Beatrice Hunter Cancer Research Institute; Nova Scotia Health Research Foundation; Cancer Research Institute","keywords":"Diacylglycerol kinase; Death-associated protein 6; Phosphocholine; Cell biology; Chemistry; Biochemistry; Lipid metabolism; Biology; Phosphatidylcholine; Phospholipid; Nuclear protein; Phosphorylation; Transcription factor; Membrane; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005955227,0.0002292006,0.0001381351,0.0001437393,0.0002098833,0.0004424582,0.0001040225,0.0001732385,0.001442408],"category_scores_gemma":[0.0001032883,0.0001192932,0.0001134498,0.0001212975,0.0002461247,0.0001920806,0.0002582331,0.0003218683,0.0006549468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005470137,"about_ca_system_score_gemma":0.0001779631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00128794,"about_ca_topic_score_gemma":0.001513255,"domain_scores_codex":[0.9999353,0.000005669584,0.000003824573,0.00001627164,0.00001462963,0.00002432689],"domain_scores_gemma":[0.9999099,0.000005724378,0.00003121454,0.000007641664,0.00001017111,0.00003544293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001017794,0.000005073081,0.0003234783,0.000009199453,8.72828e-7,0.0000414955,0.000008093441,0.00002336182,0.9991081,0.00006019025,0.00002675492,0.0002914462],"study_design_scores_gemma":[0.000016366,0.00002260737,0.01924155,0.000005567079,0.000004121437,0.0001657103,0.00004160027,0.0008749496,0.9780585,0.00007296537,0.001493645,0.000002516288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955141,0.0008740569,0.001456173,0.00008155953,0.00001379734,0.000009774321,0.0003749843,0.00006056067,0.00161499],"genre_scores_gemma":[0.995334,0.0002763785,0.0004597178,0.00002828618,0.000004805503,0.000008228883,0.0006604891,0.00003097066,0.003197164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001442408,"threshold_uncertainty_score":0.004825294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0109589333571518,"score_gpt":0.2087756907929468,"score_spread":0.197816757435795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}