{"id":"W3012434640","doi":"10.1210/endocr/bqaa035","title":"An Efficient Method for Generating Murine Hypothalamic Neurospheres for the Study of Regional Neural Progenitor Biology","year":2020,"lang":"en","type":"article","venue":"Endocrinology","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Neurosphere; Progenitor cell; Biology; Neurogenesis; Neural stem cell; Embryonic stem cell; Progenitor; Cell biology; Stem cell; Sonic hedgehog; Hypothalamus; Neuroscience; Adult stem cell; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005606594,0.000840508,0.0003970128,0.001198317,0.0005453783,0.0003246874,0.0004418075,0.0004154707,0.001354425],"category_scores_gemma":[0.0002185496,0.0002546816,0.0003693156,0.0003583261,0.0003457554,0.000338366,0.0004525481,0.0008510509,0.0007899533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002910288,"about_ca_system_score_gemma":0.0005297803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006916595,"about_ca_topic_score_gemma":0.002058287,"domain_scores_codex":[0.9996827,0.00003930412,0.00004035709,0.00006770637,0.0001341988,0.00003573402],"domain_scores_gemma":[0.9998116,0.0000381948,0.00004123207,0.00004189857,0.00003117975,0.00003583241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001776244,0.00002961233,0.00008683054,0.00006028047,0.000005482173,0.0000802366,0.00002879018,0.00007924564,0.9944317,0.0003108448,0.0001569417,0.004712348],"study_design_scores_gemma":[0.00001876617,0.0001179686,0.001724293,0.00002552966,0.00002314417,0.0005997457,0.00001820098,0.001044668,0.9764798,0.0001486087,0.019785,0.00001427159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3101996,0.01053916,0.6579921,0.0006593421,0.0006397643,0.00336557,0.005393615,0.002608369,0.008602474],"genre_scores_gemma":[0.3104347,0.009147524,0.6599771,0.000184065,0.0001169288,0.005047692,0.004855034,0.0006223829,0.009614421],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.001354425,"threshold_uncertainty_score":0.004531026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1171920483767241,"score_gpt":0.3540994083301582,"score_spread":0.2369073599534341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}