{"id":"W3012436142","doi":"10.1186/s13041-020-0555-z","title":"Upregulation of Beta4 subunit of BKCa channels in the anterior cingulate cortex contributes to mechanical allodynia associated anxiety-like behaviors","year":2020,"lang":"en","type":"article","venue":"Molecular Brain","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Natural Science Foundation of China","keywords":"Anterior cingulate cortex; Neuroscience; Postsynaptic potential; Neurotransmission; Excitatory postsynaptic potential; Downregulation and upregulation; Neuropathic pain; Chemistry; Psychology; Medicine; Internal medicine; Inhibitory postsynaptic potential; Receptor; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005218599,0.0001644051,0.0004723588,0.00009668168,0.00002775639,0.000009961266,0.0001480656,0.000127427,0.00002897781],"category_scores_gemma":[0.0003670529,0.0001316883,0.0001522891,0.0005010616,0.00002858268,0.00002722682,0.00005582074,0.0001249392,0.000003957451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004322347,"about_ca_system_score_gemma":0.00004260036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001036145,"about_ca_topic_score_gemma":0.00002544567,"domain_scores_codex":[0.9985187,0.0002203508,0.0004251829,0.000256335,0.000347512,0.0002318852],"domain_scores_gemma":[0.9993146,0.00006907318,0.0001555273,0.0002479971,0.0001108662,0.0001019303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000150919,0.000293468,0.004761805,0.00003093696,0.0001447409,0.0001131861,0.0008454351,0.00005543885,0.9923117,0.0003968963,0.00006384225,0.0008315989],"study_design_scores_gemma":[0.007258137,0.001935766,0.2296831,0.0005489977,0.0005444707,0.00001639885,0.0004224921,0.006249386,0.7520041,0.0008308717,0.0002117197,0.0002945756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904663,0.0001089231,0.004224931,0.00419015,0.00005643689,0.0008618108,0.00003838884,0.00002288336,0.00003019127],"genre_scores_gemma":[0.9964354,0.00000528445,0.0003764507,0.002989203,0.00001170207,0.00002985612,0.000100147,0.00002392886,0.00002803243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2403076,"threshold_uncertainty_score":0.5370093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01139850603097404,"score_gpt":0.2656477992412136,"score_spread":0.2542492932102395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}