{"id":"W3012438372","doi":"10.1101/2020.03.18.20037846","title":"Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase 2 Trial","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University Health Network; Princess Margaret Cancer Centre; McGill Genome Centre","funders":"National Institutes of Health; National Cancer Institute; National Human Genome Research Institute; Alvin J. Siteman Cancer Center; National Institute of Dental and Craniofacial Research; V Foundation for Cancer Research","keywords":"Pembrolizumab; Medicine; Head and neck squamous-cell carcinoma; Oncology; Internal medicine; Primary tumor; Head and neck cancer; Adjuvant; Cancer; Surgery; Immunotherapy; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002562461,0.001453958,0.001829975,0.0003513292,0.0004092178,0.000982474,0.000742574,0.001192243,0.002299222],"category_scores_gemma":[0.000852838,0.0006165833,0.001009731,0.0003139488,0.0006708846,0.0006426735,0.0003166104,0.002736213,0.0005720472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007904228,"about_ca_system_score_gemma":0.001668573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005695351,"about_ca_topic_score_gemma":0.001938583,"domain_scores_codex":[0.9994522,0.0003180793,0.00002822285,0.00008300126,0.00004199598,0.00007651059],"domain_scores_gemma":[0.9993918,0.00009360021,0.0001302232,0.000061384,0.00004909212,0.0002738556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8422832,0.06216642,0.003814381,0.000843832,0.001021724,0.0001537327,0.0001671159,0.001197157,0.03993215,0.0001588422,0.002641364,0.04561996],"study_design_scores_gemma":[0.7331573,0.2555573,0.00531622,0.00004843904,0.0004906402,0.0001470794,0.00003538554,0.0007422367,0.002619253,0.0001380153,0.001727979,0.00002020016],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99291,0.002272076,0.0003258919,0.0005123294,0.0001532806,0.002448946,0.000553325,0.00005799197,0.0007661531],"genre_scores_gemma":[0.9809325,0.002930399,0.002407557,0.001184841,0.0003835713,0.007796774,0.001598799,0.00003486126,0.002730728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002562461,"threshold_uncertainty_score":0.01355177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05034688647703978,"score_gpt":0.3739172255682665,"score_spread":0.3235703390912267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}