{"id":"W3012445641","doi":"10.3390/ncrna6010014","title":"Single Mutation in Hammerhead Ribozyme Favors Cleavage Activity with Manganese over Magnesium","year":2020,"lang":"en","type":"article","venue":"Non-Coding RNA","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"Ribozyme; Hammerhead ribozyme; Cleavage (geology); Chemistry; Ligase ribozyme; Catalysis; RNA; Stereochemistry; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000138021,0.0001679054,0.0001618875,0.00003853838,0.00005858925,0.00003603849,0.0001377663,0.0001362488,0.00004114009],"category_scores_gemma":[0.00005585017,0.0001541693,0.00005168247,0.0001333643,0.00003294814,0.00001178234,0.00005141,0.0001032371,0.00003033435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002125284,"about_ca_system_score_gemma":0.0000344782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007653247,"about_ca_topic_score_gemma":0.00008070921,"domain_scores_codex":[0.9990367,0.00006029011,0.0001336386,0.0003718003,0.0001505553,0.0002470262],"domain_scores_gemma":[0.9995929,0.00001298643,0.00008231546,0.0001962254,0.00002277828,0.00009281686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002768291,0.00005237448,0.0007039654,0.00004394546,0.00001064689,0.00004429114,0.0002511062,0.00002565397,0.9915743,0.00001452641,0.0001584925,0.006843835],"study_design_scores_gemma":[0.0005940282,0.0004982844,0.00323939,0.0000232148,0.00001194869,0.00000912468,0.0001119242,0.0002023364,0.9942825,0.00002366983,0.0007858918,0.000217676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881156,0.00005745649,0.009028031,0.000515241,0.00006953531,0.0002323782,0.000008159447,0.00002025661,0.001953342],"genre_scores_gemma":[0.9982406,0.00001009944,0.0008835754,0.0004055828,0.0001759837,0.00002253558,0.00002780221,0.00003176404,0.0002020777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01012498,"threshold_uncertainty_score":0.6286842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01663632125056919,"score_gpt":0.2321004941164713,"score_spread":0.2154641728659021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}