{"id":"W3012499363","doi":"10.1101/cshperspect.a038596","title":"Systems Biological Analysis of Immune Response to Influenza Vaccination","year":2020,"lang":"en","type":"article","venue":"Cold Spring Harbor Perspectives in Medicine","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; National Institute on Aging; National Institutes of Health; Emory University","keywords":"Vaccination; Immunogenicity; Reverse vaccinology; Immunity; Immune system; Influenza vaccine; Computational biology; Biology; Immunology; Virology; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.00155827,0.0002066669,0.00111032,0.001223036,0.00005826574,0.000008603984,0.0002172441,0.00009917461,0.0001369183],"category_scores_gemma":[0.01255391,0.000160552,0.0001409393,0.003356686,0.0001826292,0.0000614792,0.0001665688,0.0003601199,0.0000162525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004336079,"about_ca_system_score_gemma":0.00008805902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003021167,"about_ca_topic_score_gemma":0.000004604169,"domain_scores_codex":[0.997582,0.0002780964,0.0006989981,0.0004964047,0.0005971567,0.0003473477],"domain_scores_gemma":[0.9981071,0.0005637172,0.0001477107,0.000399215,0.0005258625,0.0002564184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01009631,0.0002529475,0.126437,0.000258035,0.001972462,0.0001639883,0.01882672,0.001984793,0.8286735,0.01111731,0.0001341637,0.00008275588],"study_design_scores_gemma":[0.002532593,0.001495433,0.9803926,0.0002697945,0.0003621285,4.31905e-7,0.006875054,0.002813205,0.002540495,0.000001934542,0.002564968,0.0001513722],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797867,0.01235514,0.0005380763,0.005792981,0.0000657707,0.0009010611,0.000009791196,0.00007802209,0.0004724699],"genre_scores_gemma":[0.9983212,0.0003485313,0.0003325224,0.0007151402,0.0001651288,0.00007583763,6.818466e-7,0.00001850042,0.00002246633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8539556,"threshold_uncertainty_score":0.9957638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1224601998204231,"score_gpt":0.4049403863746374,"score_spread":0.2824801865542143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}