{"id":"W3012561571","doi":"10.1002/cam4.2971","title":"Functional informed genome‐wide interaction analysis of body mass index, diabetes and colorectal cancer risk","year":2020,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Ontario Ministry of Research and Innovation; Cancer Council Victoria; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Health and Medical Research Council; Groupement des Entreprises Françaises dans la lutte contre le Cancer; National Institutes of Health; Centre Hospitalier Universitaire de Nantes; Vetenskapsrådet; Karolinska Institutet; Swedish Cancer Foundation; Bundesministerium für Bildung und Forschung; National Institute on Aging; Division of Cancer Prevention, National Cancer Institute; National Institute for Health and Care Research; Association Anne de Bretagne Genetique; Canadian Institutes of Health Research; Damon Runyon Cancer Research Foundation; Conseil Régional des Pays de la Loire; University of Cambridge; World Health Organization; Cancer Research UK; American Cancer Society; Génome Québec; Canadian Cancer Society Research Institute; McGill University; Instituto de Salud Carlos III; Xarxa de Bancs de Tumors de Catalunya; Ontario Institute for Cancer Research; Junta de Castilla y León; U.S. Department of Health and Human Services","keywords":"Body mass index; Colorectal cancer; Genome-wide association study; Heritability; Oncology; Type 2 diabetes; Missing heritability problem; Internal medicine; Insulin resistance; Diabetes mellitus; Biology; Gene–environment interaction; Genetic association; Genetics; Medicine; Gene; Bioinformatics; Genotype; Cancer; Endocrinology; Genetic variants; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001354324,0.0001009034,0.0003033242,0.00007418945,0.00004387155,0.000002392335,0.00005677726,0.0001005905,0.0003092677],"category_scores_gemma":[0.0006546958,0.00008347772,0.00006125883,0.0002658126,0.0001140452,0.000003358332,0.00003529705,0.00009037479,7.276879e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003451683,"about_ca_system_score_gemma":0.0001057554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000245965,"about_ca_topic_score_gemma":0.0002644854,"domain_scores_codex":[0.9992366,0.00004902143,0.0002671992,0.0002133777,0.00008941162,0.0001444313],"domain_scores_gemma":[0.9993777,0.00007264562,0.0002399713,0.00007906019,0.0001119534,0.0001186815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007111756,0.000005298724,0.9003534,0.00001560793,0.001025265,1.217757e-7,0.0001169871,0.003296787,0.09077469,0.00000263232,0.003234717,0.001103362],"study_design_scores_gemma":[0.0005359539,0.0002286568,0.9829768,0.000008748365,0.0006411063,1.443281e-7,0.0001898154,0.004366677,0.003091604,0.00001368615,0.007860964,0.00008582528],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933819,0.002121703,0.00155927,0.002428751,0.0001782033,0.00008757162,0.00008147876,0.000005244549,0.0001558705],"genre_scores_gemma":[0.9943959,0.003457114,0.00005592655,0.001322346,0.0003760101,0.00005144889,0.0002673433,0.000007204376,0.00006670324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08768308,"threshold_uncertainty_score":0.3404123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01320405580834194,"score_gpt":0.2801662348224676,"score_spread":0.2669621790141256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}