{"id":"W3012561571","doi":"10.1002/cam4.2971","title":"Functional informed genome‐wide interaction analysis of body mass index, diabetes and colorectal cancer risk","year":2020,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Ontario Ministry of Research and Innovation; Cancer Council Victoria; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Health and Medical Research Council; Groupement des Entreprises Françaises dans la lutte contre le Cancer; National Institutes of Health; Centre Hospitalier Universitaire de Nantes; Vetenskapsrådet; Karolinska Institutet; Swedish Cancer Foundation; Bundesministerium für Bildung und Forschung; National Institute on Aging; Division of Cancer Prevention, National Cancer Institute; National Institute for Health and Care Research; Association Anne de Bretagne Genetique; Canadian Institutes of Health Research; Damon Runyon Cancer Research Foundation; Conseil Régional des Pays de la Loire; University of Cambridge; World Health Organization; Cancer Research UK; American Cancer Society; Génome Québec; Canadian Cancer Society Research Institute; McGill University; Instituto de Salud Carlos III; Xarxa de Bancs de Tumors de Catalunya; Ontario Institute for Cancer Research; Junta de Castilla y León; U.S. Department of Health and Human Services","keywords":"Body mass index; Colorectal cancer; Genome-wide association study; Heritability; Oncology; Type 2 diabetes; Missing heritability problem; Internal medicine; Insulin resistance; Diabetes mellitus; Biology; Gene–environment interaction; Genetic association; Genetics; Medicine; Gene; Bioinformatics; Genotype; Cancer; Endocrinology; Genetic variants; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006362578,0.001445291,0.001802229,0.002624165,0.0009478534,0.001241896,0.001583347,0.001073399,0.007615604],"category_scores_gemma":[0.008967409,0.0006573626,0.004886862,0.002283698,0.0007769305,0.000524956,0.001270473,0.001322089,0.0003644582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007446624,"about_ca_system_score_gemma":0.001010733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01197319,"about_ca_topic_score_gemma":0.01400872,"domain_scores_codex":[0.9930776,0.004489716,0.0002287192,0.001398216,0.0003668874,0.0004389099],"domain_scores_gemma":[0.9917666,0.006263015,0.0005637867,0.0008313332,0.0002642746,0.000310926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01406361,0.0006002318,0.7913659,0.001038831,0.04437936,0.002336259,0.0003647378,0.03790526,0.05013666,0.004050782,0.004794043,0.04896422],"study_design_scores_gemma":[0.0007017197,0.001411331,0.7708135,0.00007304305,0.01797889,0.001221499,0.0002656863,0.1899,0.006443095,0.007404597,0.003579165,0.0002075794],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8997075,0.002446014,0.08468398,0.0008775863,0.0002005028,0.0001097872,0.009144938,0.001323272,0.001506507],"genre_scores_gemma":[0.9835768,0.0001312377,0.01297079,0.0001958235,0.00004460698,0.0001500173,0.002128139,0.0001031582,0.0006994156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01197319,"threshold_uncertainty_score":0.03364891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01320405580834194,"score_gpt":0.2801662348224676,"score_spread":0.2669621790141256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}