{"id":"W3012713937","doi":"10.1002/anie.202002019","title":"A Multi‐component All‐DNA Biosensing System Controlled by a DNAzyme","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Deoxyribozyme; Biosensor; DNA; Chemistry; RNA; Nanotechnology; Substrate (aquarium); Biophysics; Combinatorial chemistry; Biochemistry; Biology; Materials science; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001086627,0.0001866569,0.000223478,0.00003839824,0.00005918431,0.00004782879,0.0001569139,0.0001433188,0.000006075584],"category_scores_gemma":[0.0001252331,0.000167922,0.0001871318,0.00006752741,0.00005592719,0.00001132698,0.00007318054,0.00009345816,0.000009122031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006007932,"about_ca_system_score_gemma":0.00001848075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000104413,"about_ca_topic_score_gemma":0.000003265264,"domain_scores_codex":[0.9988649,0.00003004582,0.0002953109,0.0003965557,0.0002423702,0.0001707605],"domain_scores_gemma":[0.9993635,0.00001435501,0.0001824163,0.0001402724,0.0001908294,0.0001085927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002737827,0.00005532407,0.00002462274,0.00001149829,0.0001949138,0.000007660485,0.00002196955,0.000002860254,0.9758745,0.00001169544,0.02331217,0.000209033],"study_design_scores_gemma":[0.00175825,0.00007585863,0.00002080164,0.0000347222,0.00005112028,0.00001990251,0.00009465709,0.001171513,0.9666001,0.000005087836,0.02997521,0.0001927705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8010567,0.0009287692,0.1726151,0.01654972,0.001647449,0.001099478,0.0009610875,0.0007529994,0.004388636],"genre_scores_gemma":[0.9914711,0.00009267808,0.003071974,0.001731614,0.001249842,0.00001848917,0.002163965,0.00002134785,0.0001789735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1904144,"threshold_uncertainty_score":0.684766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01525351053288083,"score_gpt":0.2663800029693678,"score_spread":0.2511264924364869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}