{"id":"W3012746893","doi":"10.3390/cancers12030758","title":"MeCP2 Promotes Colorectal Cancer Metastasis by Modulating ZEB1 Transcription","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; National Natural Science Foundation of China","keywords":"Cancer research; Chromatin immunoprecipitation; Biology; Transcription factor; Metastasis; SOX2; Downregulation and upregulation; Colorectal cancer; Regulator; Cancer; Gene expression; Promoter; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002964554,0.0001319487,0.0001063047,0.00001041275,0.00006649843,0.0000173959,0.0001093821,0.00005835942,0.00006548294],"category_scores_gemma":[0.00001657234,0.0001360972,0.0000616415,0.00009214751,0.00004080697,0.000003134534,0.00002865945,0.00005741586,0.00000388144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005602823,"about_ca_system_score_gemma":0.0001485304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009451497,"about_ca_topic_score_gemma":0.00006868831,"domain_scores_codex":[0.9992276,0.00002252495,0.000128353,0.000325718,0.0001019795,0.0001938654],"domain_scores_gemma":[0.999752,0.000001930377,0.00004393445,0.00006685658,0.00002936013,0.000105856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004897464,0.000005038816,0.0003888082,0.00001832508,0.00005069012,4.933744e-7,0.0001852837,0.001408873,0.9860982,0.000003029166,0.005637873,0.006154412],"study_design_scores_gemma":[0.0004651062,0.0002170616,0.002008401,0.000007200423,0.00002568811,8.989925e-7,0.0001473511,0.001639573,0.9710184,0.000009942685,0.02423622,0.0002241586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960744,0.001961118,0.0004805625,0.0006594047,0.0001322296,0.000188536,0.0001013818,0.00001614486,0.000386265],"genre_scores_gemma":[0.9976798,0.0005834372,0.0002973386,0.00113568,0.00003986423,0.00006102353,0.0001134232,0.00002516137,0.00006429506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01859835,"threshold_uncertainty_score":0.5549883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01611788862929274,"score_gpt":0.240377658636639,"score_spread":0.2242597700073463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}