{"id":"W3012746893","doi":"10.3390/cancers12030758","title":"MeCP2 Promotes Colorectal Cancer Metastasis by Modulating ZEB1 Transcription","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; National Natural Science Foundation of China","keywords":"Cancer research; Chromatin immunoprecipitation; Biology; Transcription factor; Metastasis; SOX2; Downregulation and upregulation; Colorectal cancer; Regulator; Cancer; Gene expression; Promoter; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009154531,0.000285953,0.0001532932,0.0002565474,0.0001327526,0.0001883537,0.0001289397,0.0001589425,0.00151603],"category_scores_gemma":[0.0001195971,0.0001091053,0.0001467634,0.00014202,0.0001707376,0.0001291574,0.0002506299,0.0003551356,0.0003139326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002979568,"about_ca_system_score_gemma":0.0001762035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001028123,"about_ca_topic_score_gemma":0.001594834,"domain_scores_codex":[0.9999422,0.000007656193,0.000002998958,0.00001350247,0.0000149067,0.00001882052],"domain_scores_gemma":[0.9999455,0.000007102839,0.00001649313,0.000003307092,0.000007503567,0.00002005043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002825141,0.0000205068,0.002404074,0.0001225151,0.00001695049,0.0002203949,0.00002052148,0.0001519188,0.9933071,0.0001395326,0.0003463452,0.002967661],"study_design_scores_gemma":[0.0001567709,0.0004582532,0.08637527,0.00004066652,0.00008411246,0.001604198,0.0001261147,0.004475799,0.8931229,0.0002985349,0.01323843,0.00001909072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863046,0.006823115,0.002789582,0.0003277014,0.00003733798,0.00003070864,0.0007739234,0.0002529733,0.002659899],"genre_scores_gemma":[0.9960751,0.001197092,0.0007049961,0.00006351843,0.0000102428,0.00002158823,0.0004823541,0.00001648004,0.001428647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00151603,"threshold_uncertainty_score":0.0050717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01611788862929274,"score_gpt":0.240377658636639,"score_spread":0.2242597700073463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}