{"id":"W3012753598","doi":"10.1101/2020.03.20.988980","title":"RNA editing enzyme APOBEC3A promotes pro-inflammatory (M1) macrophage polarization","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Cancer Institute; National Institutes of Health","keywords":"Gene knockdown; RNA editing; Cytidine deaminase; RNA; Biology; Molecular biology; RNA interference; Macrophage polarization; Messenger RNA; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001068195,0.0001508892,0.0001300881,0.0001275443,0.0001633938,0.0002754724,0.00006383072,0.0002448745,0.002396649],"category_scores_gemma":[0.0001107473,0.00007146984,0.0001603112,0.00009061555,0.0001286651,0.0001051509,0.0001583302,0.0004334195,0.0007797658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002325859,"about_ca_system_score_gemma":0.0001609359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009825877,"about_ca_topic_score_gemma":0.001126366,"domain_scores_codex":[0.9999241,0.000009463789,0.000002608058,0.00001860135,0.00002122089,0.0000239688],"domain_scores_gemma":[0.9999448,0.00000995398,0.00001104199,0.000006949131,0.0000116031,0.00001558366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006916339,0.000008771689,0.0003686622,0.00002369947,0.000002776431,0.00003815295,0.000007809518,0.00005892036,0.9975414,0.0001233814,0.0002333721,0.001523866],"study_design_scores_gemma":[0.00001964616,0.0001195826,0.01279716,0.00001022787,0.0000101538,0.0002441513,0.00003453435,0.00241909,0.9766253,0.000326523,0.007388438,0.000005221277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772608,0.002958542,0.01028461,0.0004112051,0.0001153572,0.00002984757,0.001141703,0.0005453691,0.007252598],"genre_scores_gemma":[0.9929066,0.0003982462,0.001753805,0.00009484829,0.00001811203,0.00000997547,0.0004904614,0.00004712369,0.00428081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002396649,"threshold_uncertainty_score":0.0080176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01008091342257214,"score_gpt":0.2167525418155413,"score_spread":0.2066716283929692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}