{"id":"W3012962773","doi":"10.1101/2020.03.23.20041467","title":"Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia Hospital; University of Calgary; University of British Columbia; Discovery Centre","funders":"Medical Research Council; Fondazione Umberto Veronesi; Cambridge University Hospitals; Deutsche Forschungsgemeinschaft; Rosetrees Trust; Science and Technology Facilities Council; British Heart Foundation; University College London; British Society for Haematology; National Institute for Health and Care Research; Isaac Newton Trust; Dell EMC; NHS Blood and Transplant; NIHR BioResource; Swedish Orphan Biovitrum; University of Cambridge; Cancer Research UK; Wellcome Trust; Department of Health and Social Care; Engineering and Physical Sciences Research Council; CSL Behring","keywords":"Immune system; Immunology; Immune dysregulation; Platelet; Phenotype; Transcriptome; Biology; Inflammation; Fibrosis; Haematopoiesis; Medicine; Pathology; Stem cell; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001419055,0.0006414855,0.0003565105,0.0008427018,0.0002056265,0.0003054302,0.0002035005,0.000503552,0.001507593],"category_scores_gemma":[0.0004670497,0.000140644,0.0002968971,0.0004243171,0.0004570142,0.0001538268,0.000470383,0.0003325729,0.0001534403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001614551,"about_ca_system_score_gemma":0.0001137283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006902224,"about_ca_topic_score_gemma":0.0004621228,"domain_scores_codex":[0.9998114,0.00002829223,0.00001969939,0.00006549622,0.00004697954,0.000028305],"domain_scores_gemma":[0.999787,0.00005319752,0.00007616806,0.00001673917,0.00001773553,0.00004915736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00156616,0.0001049828,0.2748712,0.0003290357,0.0002898731,0.287044,0.0008965749,0.0006345928,0.4163884,0.0006853397,0.001248259,0.01594155],"study_design_scores_gemma":[0.0001158236,0.0005038611,0.5630611,0.00006361245,0.0002384099,0.3907861,0.0004537668,0.001891598,0.03832959,0.0007681139,0.003750806,0.00003738866],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982677,0.0004287862,0.0005566999,0.00006600719,0.000009812871,0.00001001496,0.0002498754,0.0000275092,0.0003836311],"genre_scores_gemma":[0.9991178,0.000138477,0.0003629643,0.00005070428,0.00001467176,0.000004705832,0.0001966425,0.000006363579,0.0001078454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001507593,"threshold_uncertainty_score":0.005043387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02256581070738401,"score_gpt":0.2649835684266352,"score_spread":0.2424177577192512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}