{"id":"W3013049033","doi":"10.1158/1078-0432.ccr-19-3519","title":"Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Institut Gustave-Roussy; National Cancer Institute; National Institutes of Health; Fondation ARC pour la Recherche sur le Cancer; Division of Arctic Sciences; CNIB","keywords":"Trametinib; Cancer research; MAPK/ERK pathway; Trisomy; Leukemia; Medicine; Biology; Immunology; Signal transduction; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001363051,0.0002450845,0.0001954793,0.0002156375,0.0001234258,0.0003648121,0.0001122947,0.000153661,0.0008928528],"category_scores_gemma":[0.0001417235,0.00009011456,0.000159427,0.0001564113,0.0001799585,0.0001231551,0.0002346366,0.0003747774,0.0001586633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002260183,"about_ca_system_score_gemma":0.0002502789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004196413,"about_ca_topic_score_gemma":0.0006976543,"domain_scores_codex":[0.9998944,0.00001824464,0.000008995564,0.00002236649,0.0000342262,0.00002183664],"domain_scores_gemma":[0.9999268,0.00001517744,0.00002774033,0.00001037346,0.000005870643,0.0000140016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003884379,0.00008112585,0.00836557,0.00007369585,0.00003019742,0.000269255,0.00001922332,0.0002851004,0.9845839,0.0001293073,0.0001066607,0.005667598],"study_design_scores_gemma":[0.0000955498,0.002529783,0.10209,0.00002754097,0.0001651211,0.006812401,0.0001167879,0.002815436,0.8764483,0.0002033951,0.008680118,0.00001557088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978665,0.0006757869,0.0005680543,0.0000340876,0.000004947384,0.00001983888,0.0003609713,0.00003058841,0.000439201],"genre_scores_gemma":[0.9980597,0.0005122143,0.0005065773,0.00002034276,0.000002297333,0.00001983205,0.0006482644,0.000005560144,0.0002251767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008928528,"threshold_uncertainty_score":0.002986848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1501579519583308,"score_gpt":0.4291317123065044,"score_spread":0.2789737603481736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}