{"id":"W3013049033","doi":"10.1158/1078-0432.ccr-19-3519","title":"Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Institut Gustave-Roussy; National Cancer Institute; National Institutes of Health; Fondation ARC pour la Recherche sur le Cancer; Division of Arctic Sciences; CNIB","keywords":"Trametinib; Cancer research; MAPK/ERK pathway; Trisomy; Leukemia; Medicine; Biology; Immunology; Signal transduction; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001786229,0.0002037211,0.0007748891,0.0001949251,0.00009727632,0.00004403852,0.0002622099,0.0002768033,0.0005365396],"category_scores_gemma":[0.001513038,0.0001460563,0.00007063605,0.00127193,0.001684882,0.0001920858,0.0002333156,0.001525258,0.00005097407],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007452093,"about_ca_system_score_gemma":0.007422396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007323758,"about_ca_topic_score_gemma":0.00003429757,"domain_scores_codex":[0.9962304,0.0004826131,0.0007395034,0.0007257673,0.001157551,0.0006641626],"domain_scores_gemma":[0.9951522,0.002931931,0.00009830609,0.000354314,0.0008957218,0.0005675472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.08437224,0.004280624,0.6245947,0.005412256,0.001750462,0.003469382,0.01022377,0.0003085682,0.1857569,0.003616485,0.01972311,0.05649142],"study_design_scores_gemma":[0.135136,0.03966896,0.1510682,0.005802262,0.000333398,0.0002496,0.009276674,0.02374782,0.5968453,0.0008113425,0.03524799,0.001812525],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879655,0.0007046657,0.0002799012,0.006557985,0.00002992389,0.001275946,0.00004165196,0.00002749138,0.003116936],"genre_scores_gemma":[0.9956802,0.001449333,0.0004267801,0.001563059,0.0001131698,0.0001758605,0.00001250195,0.00003812979,0.0005409421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4735266,"threshold_uncertainty_score":0.9982046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1501579519583308,"score_gpt":0.4291317123065044,"score_spread":0.2789737603481736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}