{"id":"W3013086220","doi":"10.1093/pcmedi/pbaa009","title":"RNA-based therapies in animal models of Leber congenital amaurosis causing blindness","year":2020,"lang":"en","type":"article","venue":"Precision Clinical Medicine","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Blindness; Medicine; Amaurosis; Genetics; Biology; Optometry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007969384,0.0007451089,0.0007498912,0.0009697095,0.0003924806,0.0005360637,0.0006723019,0.001043835,0.002073969],"category_scores_gemma":[0.0002157617,0.0002188747,0.000665598,0.0002616137,0.0005703698,0.0004121513,0.0003117625,0.001814198,0.0006270721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000747167,"about_ca_system_score_gemma":0.0004302313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00092581,"about_ca_topic_score_gemma":0.001849511,"domain_scores_codex":[0.9993931,0.0001243427,0.0000565082,0.0001155283,0.0002181181,0.00009238326],"domain_scores_gemma":[0.9997962,0.00004134803,0.00005958451,0.00002679749,0.00002729172,0.00004875592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005771673,0.0004315312,0.0001146906,0.0002191478,0.00004177829,0.0001926802,0.00003332174,0.0002774997,0.9920713,0.000562105,0.0004467798,0.00503211],"study_design_scores_gemma":[0.0003262077,0.008042128,0.001506813,0.00005440021,0.0001381827,0.0006277081,0.00005716533,0.00166763,0.9723577,0.0002816966,0.01491056,0.00002985107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9359482,0.01843501,0.02732762,0.001388599,0.0007907311,0.001464557,0.002938551,0.001968851,0.009737941],"genre_scores_gemma":[0.965124,0.007579242,0.01600184,0.0004360833,0.00006619498,0.001564248,0.001981005,0.0001156844,0.007131718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002073969,"threshold_uncertainty_score":0.006938159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1003458945866388,"score_gpt":0.3739751187459009,"score_spread":0.2736292241592621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}